R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes.
TL;DR: The data suggest that CIITA is the IFN- inducible cycloheximide sensitive factor previously shown to be required for the induction of MHC class II gene expression.
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Disruption of CD40–CD40 Ligand Interactions Results in an Enhanced Susceptibility to Leishmania amazonensis Infection
Lynn Soong,Jian Chao Xu,Iqbal S. Grewal,Peter E. Kima,Jiaren Sun,B. Jack Longley,Nancy H. Ruddle,Diane McMahon-Pratt,Richard A. Flavell +8 more
TL;DR: An essential role of cognate CD40-CD40L interactions in the generation of cellular immune responses against an intracellular parasite is indicated.
Journal ArticleDOI
A central role of CD40 ligand in the regulation of CD4+ T-cell responses
TL;DR: Examination of data from studies using gene knockout techniques that have helped provide a better understanding of CD40L's role in vivo, in regulation of the immune response is examined.
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Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation
Dean A. Le,Yongqin Wu,Zhihong Huang,Kohji Matsushita,Nikolaus Plesnila,Jean C. Augustinack,Bradley T. Hyman,Junying Yuan,Keisuke Kuida,Richard A. Flavell,Michael A. Moskowitz +10 more
TL;DR: The present study found that caspase-8 mediated poly(ADP-ribose) polymerase cleavage in caspasase-3−/− neurons in vivo and in vitro, and indicates the potential advantages of targeting more than a single caspases family member to treat ischemic cell injury.
Journal ArticleDOI
Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania.
Djalma S. Lima-Junior,Diego L. Costa,Vanessa Carregaro,Larissa D. Cunha,Alexandre L. N. Silva,Tiago W. P. Mineo,Tiago W. P. Mineo,Fredy R. S. Gutierrez,Fredy R. S. Gutierrez,Maria Bellio,Karina R. Bortoluci,Richard A. Flavell,Marcelo T. Bozza,João Santana da Silva,Dario S. Zamboni +14 more
TL;DR: It is shown that the Nlrp3 inflammasome is activated in response to Leishmania infection and is important for the restriction of parasite replication both in macrophages and in vivo as demonstrated through the infection of inflammaome-deficient mice with Leishmaniasis.