R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice
TL;DR: It is found that islets from these transgenic mice are immunogenic for naive T cells in vitro and in vivo, and mice expressing the costimulator B7-1 specifically on beta cells do not develop diabetes, suggesting that expression of the B 7-1 costimulators is not sufficient to abrogate the tolerance to peripheral antigens.
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Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo
Anthony Rongvaux,Tim Willinger,Hitoshi Takizawa,Chozhavendan Rathinam,Wojtek Auerbach,Andrew J. Murphy,David M. Valenzuela,George D. Yancopoulos,Elizabeth E. Eynon,Sean Stevens,Markus G. Manz,Richard A. Flavell +11 more
TL;DR: RAG2/−γc−/− TPO-humanized mice represent a useful model to study human hematopoiesis in vivo and maintenance of human stem and progenitor cells was improved, as demonstrated by serial transplantation.
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Inflammasome activation in infected macrophages drives COVID-19 pathology
Esen Sefik,Rihao Qu,Caroline Junqueira,Eleanna T. Kaffe,Haris Mirza,Jun Zhao,J. Richard Brewer,Ailin Han,Holly R. Steach,Benjamin Israelow,Holly N. Blackburn,Sofia E. Velazquez,Y. Grace Chen,Stephanie Halene,Akiko Iwasaki,Eric Meffre,Michel C. Nussenzweig,Judy Lieberman,Craig B. Wilen,Yuval Kluger,Richard A. Flavell +20 more
TL;DR: In this article , the authors showed that SARS-CoV-2 infection and replication in lung resident human macrophages is a critical driver of lung pathology, as inhibition of the NLRP3 inflammasome pathway reversed chronic lung pathology.
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Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity.
Nan Guo Ring,Nan Guo Ring,Dietmar Herndler-Brandstetter,Kipp Weiskopf,Liang Shan,Jens Peter Volkmer,Benson M. George,Melanie Lietzenmayer,Mckenna Kelly Marie,Tejaswitha J. Naik,Aaron McCarty,Yunjiang Zheng,Aaron M. Ring,Richard A. Flavell,Richard A. Flavell,Irving L. Weissman +15 more
TL;DR: An anti-human SIRPα antibody, KWAR23, is developed, which in combination with tumor-opsonizing antibodies, greatly augmented neutrophil and macrophage antitumor activity in vitro and in vivo and may represent a promising candidate for combination therapies.
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Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens.
Frank Wegmann,Kate H. Gartlan,Ali M. Harandi,Sarah A. Brinckmann,Margherita Coccia,William R. Hillson,Wai Ling Kok,S L Cole,Ling-Pei Ho,Teresa Lambe,Manoj Puthia,Catharina Svanborg,Erin M. Scherer,George Krashias,Adam Williams,Joseph N. Blattman,Philip D. Greenberg,Richard A. Flavell,Amin E. Moghaddam,Neil C. Sheppard,Neil C. Sheppard,Quentin J. Sattentau +21 more
TL;DR: Polyethyleneimine (PEI) represents a family of organic polycations used as nucleic acid transfection reagents in vitro and DNA vaccine delivery vehicles in vivo and it is shown that diverse PEI forms have potent mucosal adjuvant activity for viral subunit glycoprotein antigens.