R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Dissection of the interferon gamma-MHC class II signal transduction pathway reveals that type I and type II interferon systems share common signalling component(s).
TL;DR: These mutants will be useful for the study of IFN gamma regulation of class II genes and Ii chain, and to elucidate molecular components of type I and type II interferon signal transduction.
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Serologic diagnosis of Lyme disease using recombinant outer surface proteins A and B and flagellin.
Erol Fikrig,Edward D. Huguenel,Robert Berland,Daniel W. Rahn,John A. Hardin,Richard A. Flavell +5 more
TL;DR: The data suggest that recombinant B. burgdorferi antigens can serve as substrates for immunoblot and ELISA, which may be helpful in diagnosing Lyme disease.
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AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites
Lark Kyun Kim,Rimpei Morita,Yasushi Kobayashi,Stephanie C. Eisenbarth,Chun Geun Lee,Jack A. Elias,Elizabeth E. Eynon,Richard A. Flavell +7 more
TL;DR: It is found that knockin mice expressing an enzymatically inactive acidic mammalian chitinase (AMCase), the dominant true chitInase in mouse lung, showed enhanced type 2 immune responses to inhaled HDM, suggesting that AMCase is a crucial regulator of type 2immune responses to inhalation-containing aeroallergens.
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Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca.
Cintia S. de Paiva,Eugene A. Volpe,Niral B. Gandhi,Xiaobo Zhang,Xiaofen Zheng,John D. Pitcher,William J. Farley,Michael E. Stern,Jerry Y. Niederkorn,De-Quan Li,Richard A. Flavell,Stephen C. Pflugfelder +11 more
TL;DR: It is shown that disruption of TGF-β signaling in CD4+ T cells causes paradoxical improvement of dry eye disease in mice subjected to desiccating stress.
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Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells.
Siyuan Ding,Shu Zhu,Lili Ren,Ningguo Feng,Ningguo Feng,Yanhua Song,Xiaomei Ge,Bin Li,Richard A. Flavell,Harry B. Greenberg,Harry B. Greenberg +10 more
TL;DR: It is found that MAVS, critical for the host RNA sensing pathway upstream of IFN induction, is degraded by the RV RNA methyl- and guanylyl-transferase (VP3) in a host-range-restricted manner and uncovered a novel pathogen-mediated inhibitory mechanism of MAVS signaling.