R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis
Wen Pan,Shu Zhu,Dai Dai,Zheng Liu,Dan Li,Bin Li,Nicola Gagliani,Yunjiang Zheng,Yuanjia Tang,Matthew T. Weirauch,Xiaoting Chen,Wei Zhu,Yue Wang,Bo Chen,Youcun Qian,Ying-Xuan Chen,Jing-Yuan Fang,Ronald Herbst,Laura Richman,Bahija Jallal,John B. Harley,Richard A. Flavell,Yihong Yao,Nan Shen +23 more
TL;DR: It is shown that miR-125a is downregulated in peripheral CD4(+) T cells of human autoimmune diseases including systemic lupus erythematosus and Crohn's disease, and relevant autoimmune mouse models, and it is pointed to as a critical factor that controls autoimmune diseases by stabilizing Treg-mediated immune homeostasis.
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COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.
Suchithra Menon,Hongbo Chi,Hongbo Chi,Huiyong Zhang,Xing Wang Deng,Richard A. Flavell,Ning Wei +6 more
TL;DR: It is reported that T cell homeostasis and antigen-induced responses require the COP9 signalosome (CSN), a regulator of the ubiquitin-proteasome system, which is essential for antigen- induced initiation of T cell proliferation.
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TGF-β signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis
Yasmina Laouar,Terrence Town,Terrence Town,David Jeng,Elise Tran,Yisong Y. Wan,Vijay K. Kuchroo,Richard A. Flavell +7 more
TL;DR: It is found that MOG35–55 immunization of CD11cdnR mice results in strong inflammation of CNS, high frequency of T cells in CNS, increased levels of T helper 1 (TH1) and TH17 cytokines in the periphery, and lack of remission from EAE.
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Role of the Executioner Caspases during Lens Development
TL;DR: In this paper, the role of executioner caspases (caspase-3, -6, and -7) in fiber cell differentiation was determined in the mouse lens using confocal microscopy.
Journal Article
Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection.
TL;DR: It is shown that OspA-N40 immunized mice are protected against challenge with strain 297, isolated from the cerebrospinal fluid of a patient with neuroborreliosis, but not against challenge from a tick in Millbrook, NY.