R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
In Vivo Evidence for the Contribution of Human Histocompatibility Leukocyte Antigen (Hla)-Dq Molecules to the Development of Diabetes
Li Wen,F. Susan Wong,Jie Tang,Ning Yuan Chen,Martha Altieri,Chella S. David,Richard A. Flavell,Robert S. Sherwin +7 more
TL;DR: Direct in vivo evidence for the diabetogenic effect of this human MHC class II molecule is provided and a unique “humanized” animal model of spontaneous diabetes is provided.
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Regulatory role of B cells in a murine model of allergic airway disease.
Anurag K. Singh,William F. Carson,Eric R. Secor,Linda Guernsey,Richard A. Flavell,Robert B. Clark,Roger S. Thrall,Craig M. Schramm +7 more
TL;DR: A novel regulatory role for regional B cells in AAD is illustrated and a possible contributory role of B cells, along with other cell types, in the establishment of LIT is suggested.
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Regulation of c-Jun NH2-terminal Kinase ( Jnk) Gene Expression during T Cell Activation
Linda Weiss,Alan J. Whitmarsh,Derek D. Yang,Mercedes Rincon,Roger J. Davis,Richard A. Flavell +5 more
TL;DR: It is demonstrated that JNK is regulated by a second, novel mechanism that contributes to the regulation of the JNK pathway to ensure proper control during the course of an immune response.
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Innate immune cells in inflammation and cancer.
TL;DR: Basic principles of innate immune cell functions in inflammation are outlined and how these functions converge upon cancer development are discussed.
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RIG-I-mediated Activation of p38 MAPK Is Essential for Viral Induction of Interferon and Activation of Dendritic Cells DEPENDENCE ON TRAF2 AND TAK1
Susie Sommer Mikkelsen,Søren B. Jensen,Srikanth Chiliveru,Jesper Melchjorsen,Ilkka Julkunen,Matthias Gaestel,J. Simon C. Arthur,Richard A. Flavell,Sankar Ghosh,Søren R. Paludan +9 more
TL;DR: The role and mechanisms of activation of the MAPK pathway in innate immune responses induced by Sendai virus, a negative sense single-stranded RNA virus, are investigated and it is observed that TRAF2 and TAK1 were essential for RIG-I-mediated activation of p38 MAPK.