R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Gatekeeper role of brain antigen‐presenting CD11c + cells in neuroinflammation
Magdalena Paterka,Volker Siffrin,Jan Oliver Voss,Johannes Werr,Nicola Hoppmann,René Gollan,Patrick Belikan,Julia Bruttger,Jérôme Birkenstock,Steffen Jung,Enric Esplugues,Nir Yogev,Richard A. Flavell,Tobias Bopp,Frauke Zipp +14 more
TL;DR: The gatekeeper function of CNS professional antigen‐presenting CD11c+ cells is demonstrated, which preferentially interact with Th17 cells, and a fundamental role of CNS CD11C+ cells in the attraction of pathogenic T cells into and their survival within the CNS is demonstrated.
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Expression of murine H-2Kb histocompatibility antigen in cells transformed with cloned H-2 genes.
Andrew L. Mellor,L. Golden,Elisabeth H. Weiss,H. Bullman,J. Hurst,Elizabeth M. Simpson,R. James,Alain Townsend,P. M. Taylor,Walter Schmidt,Janez Ferluga,L. Leben,M. Santamaria,G. Atfield,Hilliard Festenstein,Richard A. Flavell +15 more
TL;DR: Results show that expression of the H-2Kb gene product on the L-cell surface is sufficient to make it a target for specific T-cell killing.
Journal ArticleDOI
Organization and expression of the MHC of the C57 black/10 mouse.
TL;DR: The laboratory has been studying the class I and II genes of the major histocompatibility complex (MHC) of the C57 BL/IO mouse, which encode approximately 45,000 mw polymorphic glycoproteins that are expressed as a heterodimer, with jfi-microglobulin on the surface of virtually all cells.
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ICOS Controls Effector Function but Not Trafficking Receptor Expression of Kidney-Infiltrating Effector T Cells in Murine Lupus
Jared M. Odegard,Leah D. DiPlacido,Lark Greenwald,Michael Kashgarian,Dwight H. Kono,Chen Dong,Richard A. Flavell,Richard A. Flavell,Joe Craft +8 more
TL;DR: Using genetic ablation, it is demonstrated that ICOS plays an essential role in the establishment of renal perivascular infiltrates, although a small number of infiltrating cells remain around the blood vessels.
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Antivirulence properties of an antifreeze protein.
Martin Heisig,Nabil M. Abraham,Lei Liu,Girish Neelakanta,Sarah Mattessich,Hameeda Sultana,Zhengling Shang,Juliana M. Ansari,Charlotte Killiam,Wendy E. Walker,Lynn Cooley,Richard A. Flavell,Hervé Agaisse,Erol Fikrig,Erol Fikrig +14 more
TL;DR: Data show that an antifreeze protein facilitates host control of bacterial infections and suggest therapeutic strategies for countering pathogens.