scispace - formally typeset
R

Richard A. Flavell

Researcher at Yale University

Publications -  1389
Citations -  223064

Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.

Papers
More filters
Journal ArticleDOI

The role of CTCF in regulating nuclear organization

Adam Williams, +1 more
- 14 Apr 2008 - 
TL;DR: New data now help define how C TCF mediates both long-range intrachromosomal and interchromosomal interactions, and highlight CTCF as an important factor in determining the three-dimensional structure of the genome.
Journal ArticleDOI

Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation

Binfeng Lu, +5 more
- 02 Mar 2004 - 
TL;DR: The kinetics of expression pattern of a number of transcription factors shed new light on the molecular events that shape the outcome of Th1/2 differentiation.
Journal ArticleDOI

Transforming growth factor-β: Recent advances on its role in immune tolerance

Martin A. Kriegel, +4 more
- 01 Apr 2006 - 
TL;DR: This paper focuses on T cells and natural killer cells, which are directly regulated by TGF-β in vivo, and discusses recent advances on the role of TGF -β in immune-mediated diabetes, inflammatory bowel disease, arthritis, and systemic lupus erythematosus.
Journal ArticleDOI

Zero-preserving imputation of single-cell RNA-seq data

George C. Linderman, +6 more
- 11 Jan 2022 - 
TL;DR: In this article , a method based on low-rank matrix approximation is proposed to estimate the true biological zero values while preserving biologically nonexpressed genes (true biological zero) at zero expression levels.
Journal ArticleDOI

Expression of Transgene Encoded TGF-β in Islets Prevents Autoimmune Diabetes in NOD Mice by a Local Mechanism

Iqbal S. Grewal, +14 more
- 01 Aug 2002 - 
TL;DR: Results suggest that TGF-beta protects islets by a local event in insulin dependent diabetes mellitus and increased apoptosis of invading cells when compared to non-transgenic NOD mice.