R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
Papers
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Journal ArticleDOI
Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells
Yasushi Takai,Tiina Matikainen,Andrea Jurisicova,Mee Ran Kim,Alexander M. Trbovich,E. Fujita,Toshiyuki Nakagawa,Bénédicte Lemmers,Richard A. Flavell,Razqallah Hakem,Takashi Momoi,Junying Yuan,Jonathan L. Tilly,G. I. Perez +13 more
TL;DR: Interestingly, DKO oocytes were more resistant to apoptosis induced by methotrexate (MTX) than WT oocytes, and these results revealed that in female germ cells, insults that directly interfere with their metabolic status require caspase-2 and caspasing-3 as obligatory executioners of the ensuing cell death cascade.
Journal ArticleDOI
Protection against antigenically variable Borrelia burgdorferi conferred by recombinant vaccines.
Sam R. Telford,Erol Fikrig,Stephen W. Barthold,Laura Rosa Brunet,Andrew Spielman,Richard A. Flavell +5 more
TL;DR: It is concluded that Osp vaccination of mice effectively prevents infection by the agent of Lyme disease in a simulated natural cycle of transmission.
Journal Article
Breaking immunologic ignorance to an antigenic peptide of simian virus 40 large T antigen.
TL;DR: A model in which a nononcogenic, yet antigenic, fragment of the SV40-T (SV40- Tfrag) is expressed specifically in pancreatic islet beta-cells demonstrates that in some circumstances the presence of (primed) reactive T cells is not sufficient to break tolerance; rather, costimulation is additionally required to elicit an autoimmune response.
Journal ArticleDOI
Oct-1 Regulates IL-17 Expression by Directing Interchromosomal Associations in Conjunction with CTCF in T Cells
Lark Kyun Kim,Enric Esplugues,Cornelia E. Zorca,Fabio Parisi,Yuval Kluger,Tae Hoon Kim,Niels Galjart,Richard A. Flavell +7 more
TL;DR: Collectively, the data indicate Th17 lineage differentiation is restrained by the Th2 locus via interchromosomal associations organized by Oct-1 and CTCF.
Patent
Compositions and methods for the prevention and diagnosis of lyme disease
TL;DR: A screening method for the selection of those OspA and OspB polypeptides and anti-OspB antibodies that are useful for the prevention and detection of Lyme disease is presented in this paper.