R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
Papers
More filters
Journal ArticleDOI
Role of Cathepsin S-Dependent Epithelial Cell Apoptosis in IFN-γ-Induced Alveolar Remodeling and Pulmonary Emphysema
Tao Zheng,Min-Jong Kang,Kristina Crothers,Zhou Zhu,Wei Liu,Chun Geun Lee,Lesley A. Rabach,Harold A. Chapman,Robert J. Homer,Robert J. Homer,David Aldous,George DeSanctis,Underwood Stephen Leslie,Michael Graupe,Richard A. Flavell,John A. Schmidt,Jack A. Elias +16 more
TL;DR: It is demonstrated that cathepsin S-dependent epithelial cell apoptosis is a critical event in the pathogenesis of IFN-γ-induced alveolar remodeling and emphysema and link inflammation, protease/antiprotease alterations, and protease-dependent apoptosis in the Pathogenesis of Th1/Tc1 cytokine-induced tissue remodelling and destructive responses.
Journal ArticleDOI
Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient mice.
TL;DR: Intercrosses of C57BL/6J and 129X1/SvJ mutants revealed that the vast majority of caspase-3−/− F1 mice displayed the severe 129X 1/SVJ-“like” phenotype, consistent with an incompletely penetrant strain-dependent genetic modifier (or modifiers) that alters the neurodevelopmental consequences of cazase- 3 deficiency.
Journal ArticleDOI
TLR-Independent Induction of Dendritic Cell Maturation and Adaptive Immunity by Negative-Strand RNA Viruses
Carolina B. López,Bruno Moltedo,Lena Alexopoulou,Laura Bonifaz,Richard A. Flavell,Thomas M. Moran +5 more
TL;DR: The data presented here provide evidence for the existence of a novel intracellular pathway independent of TLR-mediated signaling responsible for live virus triggering of DC maturation and demonstrate its critical role in the onset of antiviral immunity.
Journal ArticleDOI
The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation
Neesar Ahmed,Minghui Zeng,Indrajit Sinha,Lisa Polin,Wei Zen Wei,Chozhavendan Rathinam,Richard A. Flavell,Ramin Massoumi,K. Venuprasad +8 more
TL;DR: It is demonstrated that E3 ligase Itch and deubiquitinase Cyld formed a complex via interaction through 'WW-PPXY' motifs that led to chronic production of tumor-promoting cytokines by tumor-associated macrophages and aggressive growth of lung carcinoma.
Journal ArticleDOI
Renalase deficiency aggravates ischemic myocardial damage
Yanling Wu,Jianchao Xu,Heino Velazquez,Peili Wang,Guoyong Li,Dinggang Liu,Benedita Sampaio-Maia,Janete Quelhas-Santos,Kerry S. Russell,Raymond R. Russell,Richard A. Flavell,Manuel Pestana,Frank J. Giordano,Gary V. Desir +13 more
TL;DR: In this article, the authors showed that renalase deficiency in a mouse knockout model causes increased plasma catecholamine levels and hypertension, and that recombinant renalase completely rescued the cardiac phenotype.