R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Death of a Monopoly
TL;DR: Cavitation, an early developmental process in the mouse embryo that requires cell death, has now been suggested to occur through a caspase-independent pathway that instead uses a mitochondrial protein called AIF (apoptosis-inducing factor).
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BID-D59A Is a Potent Inducer of Apoptosis in Primary Embryonic Fibroblasts
TL;DR: This article showed that expression of a caspase-8 non-cleavable BID-D59A mutant or expression of wild type (wt) BID induces apoptosis.
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Bax, Caspase-2, and Caspase-3 Are Required for Ovarian Follicle Loss Caused by 4-Vinylcyclohexene Diepoxide Exposure of Female Mice in Vivo
Yasushi Takai,Jacqueline Canning,Gloria I. Perez,James K. Pru,Jennifer J. Schlezinger,David H. Sherr,Richard Kolesnick,Junying Yuan,Richard A. Flavell,Stanley J. Korsmeyer,Jonathan L. Tilly +10 more
TL;DR: It is concluded that Bax, caspase-2, and caspasase-3, but not ASMase or Ahr, are functionally important in VCD-induced follicle loss.
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Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients.
Frank Waldron-Lynch,Octavian Henegariu,Songyan Deng,Paula Preston-Hurlburt,James E. Tooley,Richard A. Flavell,Kevan C. Herold +6 more
TL;DR: The findings demonstrate that humanized mice may be used to identify novel immunologic mechanisms that occur in patients treated with immunomodulators, and suggest mechanisms of drug action in murine models that have not been confirmed in clinical studies.
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m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity
Jing Zhou,Jing Zhou,Xingli Zhang,Jiajia Hu,Rihao Qu,Zhibin Yu,Hao Xu,Huifang Chen,Lichong Yan,Chenbo Ding,Chenbo Ding,Qiang Zou,Youqiong Ye,Zhengting Wang,Richard A. Flavell,Hua-Bing Li,Hua-Bing Li +16 more
TL;DR: In this article, the authors showed that ALKBH5 deficiency increased m6A modification on interferon-γ and C-X-C motif chemokine ligand 2 messenger RNA (mRNA), thus decreasing their mRNA stability and protein expression in CD4+ T cells.