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Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Generation of Genetically Modified Mice Using the CRISPR–Cas9 Genome-Editing System
Jorge Henao-Mejia,Adam Williams,Anthony Rongvaux,Judith Stein,Cynthia Hughes,Richard A. Flavell +5 more
TL;DR: The recently described CRISPR-Cas9 genome-editing technology significantly reduces the time and the cost that are required to generate genetically engineered mice, allowing scientists to test more precise and bold hypotheses in vivo.
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The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity
Pamela Y. Chan,Eugenio Antonio Carrera Silva,Eugenio Antonio Carrera Silva,Dimitri A. de Kouchkovsky,Leonel Joannas,Liming Hao,Donglei Hu,Scott Huntsman,Celeste Eng,Paula Licona-Limón,Jason S. Weinstein,De'Broski R. Herbert,Joe Craft,Richard A. Flavell,Richard A. Flavell,Silvia A. Repetto,Jorge Correale,Esteban G. Burchard,Dara G. Torgerson,Sourav Ghosh,Carla V. Rothlin +20 more
TL;DR: It is shown that genetic ablation of a receptor tyrosine kinase encoded by Tyro3 in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity.
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Shaping of Intestinal Microbiota in Nlrp6- and Rag2-Deficient Mice Depends on Community Structure
Eric J. C. Gálvez,Aida Iljazovic,Achim Gronow,Richard A. Flavell,Richard A. Flavell,Till Strowig +5 more
TL;DR: The results show that the impact of Nlrp6 and also of adaptive immunity on microbiota composition depends on community structure and primarily influences pathobionts but not commensals.
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Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse.
Susan Wong,Sylvie Guerder,Irene Visintin,Eva-Pia Reich,Karl E Swenson,Richard A. Flavell,Charles A. Janeway +6 more
TL;DR: Transgenic mice have been generated that express B7-1 on the β-cells of the pancreatic islets of Langerhans and this illustrates that B 7-1 is a very potent co-stimulatory molecule in vivo and that its presence on the surface of tissue cells can potentiate the autoimmune process.
Journal Article
Regulation of the activity of IFN-gamma promoter elements during Th cell differentiation.
Feng Zhang,Ding Zhe Wang,Mark Boothby,Laurie A. Penix,Richard A. Flavell,Richard A. Flavell,Thomas M. Aune +6 more
TL;DR: Data suggest that both de-repression and trans-activation contribute to the induction of IFN-gamma gene transcription during Th1 differentiation.