R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis
Sarah R. Barger,Nicholas S. Reilly,Maria S. Shutova,Qingsen Li,Paolo Maiuri,John M. Heddleston,Mark S. Mooseker,Richard A. Flavell,Richard A. Flavell,Tatyana Svitkina,Patrick W. Oakes,Mira Krendel,Nils C. Gauthier +12 more
TL;DR: It is shown that myosin 1e and myOSin 1f link the actin cytoskeleton to the membrane and are required for efficient phagocytosis of antibody-opsonized targets and supports a mechanism involving membrane-cytoskeletal crosstalk forphagocytic cup closure.
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Interaction between Kb and Q4 gene sequences generates the Kbm6 mutation.
Jan Geliebter,Richard A. Zeff,Dan H. Schulze,Larry R. Pease,Elisabeth H. Weiss,Andrew L. Mellor,Richard A. Flavell,Stanley G. Nathenson +7 more
TL;DR: Because the Kbm6 mutation arose in an homozygous mouse these data indicate that the Q4 gene contains the only donor sequence and demonstrates that Q-region gene sequences can interact with the Kb gene to generate variant K molecules.
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Cooperation between Multiple Microbial Pattern Recognition Systems Is Important for Host Protection against the Intracellular Pathogen Legionella pneumophila
Kristina A. Archer,Florence Ader,Florence Ader,Koichi Kobayashi,Richard A. Flavell,Craig R. Roy +5 more
TL;DR: Activation of the Rip2, MyD88, and Naip5/NLRC4 signaling pathways triggers a coordinated and synergistic response that protects the host against lethal infection by L. pneumophila, the causative agent of a severe pneumonia called Legionnaires' disease.
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The DNA sequence of the 5′ flanking region of the human 0-gk bin gene: evolutionary conservation and polymorphic differences
TL;DR: The DNA sequence of a 1464 bp segment immediately flanking the 5' side of the human beta-globin gene is determined and it is not yet clear whether this HinfI site will have any value in prenatal diagnosis of beta thalassaemia.
Journal Article
The TCR zeta-chain immunoreceptor tyrosine-based activation motifs are sufficient for the activation and differentiation of primary T lymphocytes.
TL;DR: The results show that the zeta-chain ITAMs, in the absence of the gamma, delta, and epsilon ITams, are sufficient for the activation and functional maturation of primary T lymphocytes, and supports the isolated use of the zetas in the development of surrogate TCRs for therapeutic purposes.