R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Amino-termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation.
Maile R. Brown,Jack Kronengold,Valeswara-Rao Gazula,Charalampos G. Spilianakis,Richard A. Flavell,Christian A. A. von Hehn,Arin Bhattacharjee,Leonard K. Kaczmarek +7 more
TL;DR: It is determined that alternative RNA splicing gives rise to at least five different transcripts for Slack, which produce Slack channels that differ in their predicted cytoplasmic amino‐termini and in their kinetic properties.
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Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration
Jayendra Kumar Krishnaswamy,Arpita Singh,Uthaman Gowthaman,Renee Wu,Pavane Gorrepati,Manuela Sales Lima Nascimento,Antonia Gallman,Dong Liu,Anne Marie Rhebergen,Samuele Calabro,Lan Xu,Patricia Ranney,Anuj Srivastava,Matthew S. Ranson,James D. Gorham,Zachary R. McCaw,Steven R. Kleeberger,Leonhard X. Heinz,André C. Müller,Keiryn L. Bennett,Giulio Superti-Furga,Jorge Henao-Mejia,Fayyaz S. Sutterwala,Adam Williams,Richard A. Flavell,Stephanie C. Eisenbarth +25 more
TL;DR: DOCK8 is an important regulator of DC migration during an immune response and is prone to mutations that disrupt its crucial function, which confirms the essential function of DOCK8 in the immune system.
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Lymphotoxin-β-deficient mice show defective antiviral immunity
Dietmar P. Berger,Denise Naniche,Mary T. Crowley,Pandelakis A. Koni,Richard A. Flavell,Michael B. A. Oldstone +5 more
TL;DR: It is indicated that the absence of LTβ does not affect the intrinsic function of T lymphocytes or of dendritic cells but that the structural integrity of the spleen is strongly associated with generation of antiviral immunity.
Journal ArticleDOI
Conversion of a PI-anchored protein to an integral membrane protein by a single amino acid mutation
TL;DR: The predicted transmembrane segment of Qa-2 differs from those of H-2 K, D, and L by the presence of an aspartate in place of a valine at position 295 as mentioned in this paper.
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Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice
Yasuyuki Saito,Yasuyuki Saito,Jana M. Ellegast,Anahita Rafiei,Yuanbin Song,Daniel Kull,Mathias Heikenwalder,Mathias Heikenwalder,Anthony Rongvaux,Anthony Rongvaux,Stephanie Halene,Richard A. Flavell,Richard A. Flavell,Markus G. Manz +13 more
TL;DR: In this paper, the authors transplanted mobilized peripheral blood (PB) CD34+ cells in sublethally irradiated newborn and adult recipients and found that the transplanted PB cells showed higher engraftment levels in bone marrow, spleen, and PB in newborn transplanted MSTRG/MISTRG as compared with nonobese diabetic/severe combined immunodeficient Il2rg-/- or human SIRPα-transgenic Rag2-/-Il2rg+/- recipients.