Kuvempu University

About: Kuvempu University is a education organization based out in Shimoga, India. It is known for research contribution in the topics: Cyclic voltammetry & Carbon paste electrode. The organization has 1575 authors who have published 2210 publications receiving 39755 citations. The organization is also known as: KU.

A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway

Abstract: Receptor activator of nuclear factor-kappa B ligand (RANKL) is a member of tumor necrosis factor (TNF) superfamily that plays a key role in the regulation of differentiation, activation and survival of osteoclasts and also in tumor cell migration and bone metastasis. Osteoclast activation induced by RANKL regulates hematopoietic stem cell mobilization as part of homeostasis and host defense mechanisms thereby linking regulation of hematopoiesis with bone remodeling. Binding of RANKL to its receptor, Receptor activator of nuclear factor-kappa B (RANK) activates molecules such as NF-kappa B, mitogen activated protein kinase (MAPK), nuclear factor of activated T cells (NFAT) and phosphatidyl 3-kinase (PI3K). Although the molecular and cellular roles of these molecules have been reported previously, a systematic cataloging of the molecular events induced by RANKL/RANK interaction has not been attempted. Here, we present a comprehensive reaction map of the RANKL/RANK-signaling pathway based on an extensive manual curation of the published literature. We hope that the curated RANKL/RANK-signaling pathway model would enable new biomedical discoveries, which can provide novel insights into disease processes and development of novel therapeutic interventions. Database URL: http://www.netpath.org/pathways?path_id=NetPath_21

Enhancement of radiation on hydromagnetic Casson fluid flow towards a stretched cylinder with suspension of liquid-particles

Abstract: The presence of dust particles is involved in many engineering and industrial processes like transport of petroleum, emission of smoke from vehicles, piping of power plants, treatment of waste-water and corrosive particles in mining. Due to such importance of this phenomenon, we considered the Casson liquid flow past a stretching hollow cylinder with fluid-particle suspension and convective boundary condition aspects. Numerical solution is obtained via shooting techniques after the applying of similarity variables to the governing partial equations. Key parameters of problem are discussed through graphs. It is noticed that the clean fluid temperature is always higher values as compared to dust fluid and also presence of radiation enhanced the temperature at the surface.