Kuvempu University

About: Kuvempu University is a education organization based out in Shimoga, India. It is known for research contribution in the topics: Cyclic voltammetry & Carbon paste electrode. The organization has 1575 authors who have published 2210 publications receiving 39755 citations. The organization is also known as: KU.

Synthesis, antimicrobial, and antioxidant activity of benzofuran barbitone and benzofuran thiobarbitone derivatives

Abstract: The synthesis of novel series of benzofuran derivatives, containing barbitone moiety, 5-[(2/4-substitutedphenyl)(5-substituted-1-benzofuran-2-yl) methylidene]pyrimidin-2,4,6(1H,3H,5H)-trione (4a–i) and thiobarbitone moiety, 5-[(2/4-substitutedphenyl)(5-substituted-1-benzofuran-2-yl)methylidene]-2-thioxodihydropyrimidin-4,6(1H, 5H)-dione (5a–i) have been reported. The target compounds (4a–i) and (5a–i) were synthesized by the Knoevenagel condensation of (5-substituted-1-benzofuran-2-yl)(2/4-substitutedphenyl) methanone (3a–i) with barbituric acid and thiobarbituric acid, respectively, in acid medium. These compounds were screened for the antimicrobial and antioxidant activities. From antimicrobial activity results it was found that compounds 4a, 5a, 4c, and 5c displayed good antibacterial and antifungal activity against all tested strains. Further, the synthesized compounds were studied for docking on the enzyme, Glucosamine-6-phosphate synthase and the compounds 4c and 5c have emerged has an active antimicrobial agent with least binding energy (−5.27 and −4.85 kJ mol−1). Compounds 4e, 4f, 5e, and 5f showed promising free radical scavenging activity and compounds 5a and 5b showed good chelating ability with Fe2+ ions.

Exponential space-dependent heat generation impact on MHD convective flow of Casson fluid over a curved stretching sheet with chemical reaction

Abstract: The present article focuses on the effect of exponential space-dependent heat source on magneto-hydrodynamic Casson fluid flow over a curved stretching sheet along with chemical reaction and convective heat and mass flux boundary conditions. The equations that govern the flow are reduced from system of partial differential equations to system of ordinary differential equations with the assistance of similarity transformations, and after that, they are solved using the numerical technique Runge–Kutta–Fehlberg fourth–fifth-order method. The obtained numerical values are plotted through graphs for velocity, temperature and concentration profiles with various parameters, and the variations based on these plots are discussed. Here, it is incurred that the velocity and concentration fields increase with increasing curvature parameter, whereas temperature profile shows inverse relation. Also, increment of Casson parameter shows the significant change in all flow profiles. Both thermal Biot number and concentration Biot number have increasing impact on temperature and concentration profiles, respectively.