University of Wisconsin–Milwaukee

About: University of Wisconsin–Milwaukee is a education organization based out in Milwaukee, Wisconsin, United States. It is known for research contribution in the topics: Population & Gravitational wave. The organization has 11839 authors who have published 28034 publications receiving 936438 citations. The organization is also known as: UWM & University of Wisconsin-Milwaukee.

Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study

Abstract: Objective The aim of this study was to examine the putative adverse effects of ambient fine particulate matter (PM2.5: PM with aerodynamic diameters <2.5μm) on brain volumes in older women. Methods We conducted a prospective study of 1,403 community-dwelling older women without dementia enrolled in the Women's Health Initiative Memory Study, 1996–1998. Structural brain magnetic resonance imaging scans were performed at the age of 71–89 years in 2005–2006 to obtain volumetric measures of gray matter (GM) and normal-appearing white matter (WM). Given residential histories and air monitoring data, we used a spatiotemporal model to estimate cumulative PM2.5 exposure in 1999–2006. Multiple linear regression was employed to evaluate the associations between PM2.5 and brain volumes, adjusting for intracranial volumes and potential confounders. Results Older women with greater PM2.5 exposures had significantly smaller WM, but not GM, volumes, independent of geographical region, demographics, socioeconomic status, lifestyles, and clinical characteristics, including cardiovascular risk factors. For each interquartile increment (3.49μg/m3) of cumulative PM2.5 exposure, the average WM volume (WMV; 95% confidence interval) was 6.23cm3 (3.72–8.74) smaller in the total brain and 4.47cm3 (2.27–6.67) lower in the association areas, equivalent to 1 to 2 years of brain aging. The adverse PM2.5 effects on smaller WMVs were present in frontal and temporal lobes and corpus callosum (all p values <0.01). Hippocampal volumes did not differ by PM2.5 exposure. Interpretation PM2.5 exposure may contribute to WM loss in older women. Future studies are needed to determine whether exposures result in myelination disturbance, disruption of axonal integrity, damages to oligodendrocytes, or other WM neuropathologies. Ann Neurol 2015;78:466–476

The Lyα Properties of Faint Galaxies at z ~ 2-3 with Systemic Redshifts and Velocity Dispersions from Keck-MOSFIRE

Abstract: We study the Lyα profiles of 36 spectroscopically detected Lyα-emitters (LAEs) at z ~ 2-3, using Keck MOSFIRE to measure systemic redshifts and velocity dispersions from rest-frame optical nebular emission lines. The sample has a median optical magnitude R = 26.0, and ranges from R ≃ 23 to R > 27, corresponding to rest-frame UV absolute magnitudes M _(UV) ≃ –22 to M ^(UV) > –18.2. Dynamical masses range from M_(dyn) 3σ significance: brighter galaxies with larger velocity dispersions tend to have larger values of Δv Lyα. We also make use of a comparison sample of 122 UV-color-selected R < 25.5 galaxies at z ~ 2, all with Lyα emission and systemic redshifts measured from nebular emission lines. Using the combined LAE and comparison samples for a total of 158 individual galaxies, we find that Δv_(Lyα) is anti-correlated with the Lyα equivalent width with 7σ significance. Our results are consistent with a scenario in which the Lyα profile is determined primarily by the properties of the gas near the systemic redshift; in such a scenario, the opacity to Lyα photons in lower mass galaxies may be reduced if large gaseous disks have not yet developed and if the gas is ionized by the harder spectrum of young, low metallicity stars.