Institution
University of Wisconsin–Milwaukee
Education•Milwaukee, Wisconsin, United States•
About: University of Wisconsin–Milwaukee is a education organization based out in Milwaukee, Wisconsin, United States. It is known for research contribution in the topics: Population & Gravitational wave. The organization has 11839 authors who have published 28034 publications receiving 936438 citations. The organization is also known as: UWM & University of Wisconsin-Milwaukee.
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University of Washington1, University of Cambridge2, University of Leicester3, University of Lübeck4, University of Copenhagen5, University of Wisconsin–Milwaukee6, University of Michigan7, Montreal Heart Institute8, University of Oxford9, Broad Institute10, Samsung Medical Center11, University of Amsterdam12, Queen Mary University of London13, University of Göttingen14, University of Dundee15, University of Verona16, Vanderbilt University17, University of Kiel18, University of Bonn19, University of Basel20, Norwegian University of Science and Technology21, Umeå University22, University of Duisburg-Essen23, Technische Universität München24, University of Tartu25, Lund University26, University of Ottawa27, King Abdulaziz University28, Merck & Co.29, Ohio State University30, National Institutes of Health31, Johns Hopkins University32, Harvard University33, University of Insubria34, University of Glasgow35, Leiden University36, Queen's University Belfast37, Pierre-and-Marie-Curie University38, Wellcome Trust Sanger Institute39, University of Leeds40, Duke University41, University of Pennsylvania42
TL;DR: It was found that carriers of loss-of-function mutations in ANGPTL4 had triglyceride levels that were lower than those among noncarriers; these mutations were also associated with protection from coronary artery disease.
Abstract: BACKGROUND The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. METHODS Through DNA genotyping, we ...
339 citations
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TL;DR: In this paper, the authors compare specific assessments of police performance with more global attitudes toward the police, and show that the two measures produce similar levels of support for the police in a large midwestern city.
Abstract: Since the 1960s, a substantial body of research has focused on citizens' attitudes toward the police. These studies tap a rather wide variety of outlooks: some ask about specific assessments of the police (e.g., satisfaction with the police in particular incidents), while others ask about more global assessments (e.g., satisfaction with the police in general, police in the community, or police in the neighborhood). Using data obtained through a panel survey of 398 residents of a large midwestern city, we compare specific assessments of police performance with more global attitudes toward the police. We also examine the effects of global and specific attitudes on one another. The results show that the two measures produce similar levels of support for the police. The results reveal further that global attitudes have substantial effects on specific assessments of police performance, and that the effects of specific assessments of police performance on global attitudes are modest by comparison.
338 citations
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TL;DR: A role of oxygen free radicals in causing abnormality of female reproduction in mammals is suggested for the first time, through a gain-of-function mechanism.
337 citations
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TL;DR: It is shown that c-type cytochromes of a dissimilatory metal-reducing bacterium, Shewanella oneidensis MR-1, are essential for the reduction of U(VI) and formation of extracelluar UO 2 nanoparticles and this is the first study to the authors' knowledge to directly localize the OM-associated cyto Chromes with EPS, which contains biogenic UO2 nanoparticles.
Abstract: Modern approaches for bioremediation of radionuclide contaminated environments are based on the ability of microorganisms to effectively catalyze changes in the oxidation states of metals that in turn influence their solubility. Although microbial metal reduction has been identified as an effective means for immobilizing highly-soluble uranium(VI) complexes in situ, the biomolecular mechanisms of U(VI) reduction are not well understood. Here, we show that c-type cytochromes of a dissimilatory metal-reducing bacterium, Shewanella oneidensis MR-1, are essential for the reduction of U(VI) and formation of extracelluar UO 2 nanoparticles. In particular, the outer membrane (OM) decaheme cytochrome MtrC (metal reduction), previously implicated in Mn(IV) and Fe(III) reduction, directly transferred electrons to U(VI). Additionally, deletions of mtrC and/or omcA significantly affected the in vivo U(VI) reduction rate relative to wild-type MR-1. Similar to the wild-type, the mutants accumulated UO 2 nanoparticles extracellularly to high densities in association with an extracellular polymeric substance (EPS). In wild-type cells, this UO 2-EPS matrix exhibited glycocalyx-like properties and contained multiple elements of the OM, polysaccharide, and heme-containing proteins. Using a novel combination of methods including synchrotron-based X-ray fluorescence microscopy and high-resolution immune-electron microscopy, we demonstrate a close association of the extracellular UO 2 nanoparticles with MtrC and OmcA (outer membrane cytochrome). This is the first study to our knowledge to directly localize the OM-associated cytochromes with EPS, which contains biogenic UO 2 nanoparticles. In the environment, such association of UO 2 nanoparticles with biopolymers may exert a strong influence on subsequent behavior including susceptibility to oxidation by O 2 or transport in soils and sediments.
336 citations
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TL;DR: Although there is much interest in the effects of sperm competition on sexual dimorphism, this work suggests that traditional explanations based on social mating systems are better predictors ofDimorphism in birds.
Abstract: Comparative analyses suggest that a variety of factors influence the evolution of sexual dimorphism in birds. We analyzed the relative importance of social mating system and sperm competition to sexual differences in plumage and body size (mass and tail and wing length) of more than 1000 species of birds from throughout the world. In these analyses we controlled for phylogeny and a variety of ecological and life-history variables. We used testis size (corrected for total body mass) as an index of sperm competition in each species, because testis size is correlated with levels of extrapair paternity and is available for a large number of species. In contrast to recent studies, we found strong and consistent effects of social mating system on most forms of dimorphism. Social mating system strongly influenced dimorphism in plumage, body mass, and wing length and had some effect on dimorphism in tail length. Sexual dimorphism was relatively greater in species with polygynous or lekking than monogamous mating systems. This was true when we used both species and phylogenetically independent contrasts for analysis. Relative testis size was also related positively to dimorphism in tail and wing length, but in most analyses it was a poorer predictor of plumage dimorphism than social mating system. There was no association between relative testis size and mass dimorphism. Geographic region and life history were also associated with the four types of dimorphism, although their influence varied between the different types of dimorphism. Although there is much interest in the effects of sperm competition on sexual dimorphism, we suggest that traditional explanations based on social mating systems are better predictors of dimorphism in birds.
336 citations
Authors
Showing all 11948 results
Name | H-index | Papers | Citations |
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Caroline S. Fox | 155 | 599 | 138951 |
Mark D. Griffiths | 124 | 1238 | 61335 |
Benjamin William Allen | 124 | 807 | 87750 |
James A. Dumesic | 118 | 615 | 58935 |
Richard O'Shaughnessy | 114 | 462 | 77439 |
Patrick Brady | 110 | 442 | 73418 |
Laura Cadonati | 109 | 450 | 73356 |
Stephen Fairhurst | 109 | 426 | 71657 |
Benno Willke | 109 | 508 | 74673 |
Benjamin J. Owen | 108 | 351 | 70678 |
Kenneth H. Nealson | 108 | 483 | 51100 |
P. Ajith | 107 | 372 | 70245 |
Duncan A. Brown | 107 | 567 | 68823 |
I. A. Bilenko | 105 | 393 | 68801 |
F. Fidecaro | 105 | 569 | 74781 |