Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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Extracellular matrix and angiogenic factors in hematological diseases
Daniela Filipa,Nobre Salvador +1 more
TL;DR: Dissertacao de mest, Ciencias Biomedicas, Departamento de Ciences Biomedica e Medicina, Univ. do Algarve, 2011.
Dissertation
Thérapie cellulaire pour le glaucome : régénération tissulaire grâce aux cellules souches mésenchymateuses
Journal ArticleDOI
Large-scale production of foreign proteins via the novel plant transient expression system in Pisum sativum L.
Liang Li,Liang Li,Xiufeng Wang,Liping Yang,Liping Yang,Yajun Fan,Yajun Fan,Xiaojuan Zhu,Xingzhi Wang +8 more
TL;DR: The in planta infiltration system described here provides a powerful tool to explore easily gene expression in Pisum sativum L. avoiding tissue culture steps and the labor-intensive generation of transgenic plants.
Book ChapterDOI
FGFR4 as a Biomarker in Squamous Cell Cancers of the Mouth and Oropharynx
Roberta Lelis Dutra,Marcelo dos Santos,Suzanny Oliveira Mendes,Gabriela Tonini Peterle,Iúri Drumond Louro,Adriana Madeira Álvares da Silva Conforti +5 more
Dissertation
The role of keratinocyte growth factor and receptor in gingival hyperplasia
TL;DR: KGF and KGFR are up-regulated in GH compared with NG tissues and also in response to the drugs in vitro, and suggest that KGF and its receptor play a fundamental part in the molecular pathology of GH.
References
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Journal ArticleDOI
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
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Protein modules and signalling networks
TL;DR: This work highlights conserved protein domains that act as key regulatory participants in many of these different signalling pathways in multicellular organisms.
Journal ArticleDOI
Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
Journal ArticleDOI
Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.