Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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Basic fibroblast growth factor enhances PPARγ ligand-induced adipogenesis of mesenchymal stem cells
Markus Neubauer,Claudia Fischbach,Petra Bauer-Kreisel,Esther Lieb,Michael C. Hacker,Joerg Tessmar,Michaela B. Schulz,Achim Goepferich,Torsten Blunk +8 more
TL;DR: It is demonstrated on the cellular and molecular level that supplementation of bFGF in different phases of cell culture leads to a strong enhancement of adipogenesis of MSCs, as induced by an adipogenic hormonal cocktail.
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Regulation of osteoblast differentiation: a novel function for fibroblast growth factor 8.
Maija P. Valta,Teuvo Hentunen,Qiang Qu,Eeva M. Valve,Anna Harjula,Jani Seppänen,H. Kalervo Väänänen,Pirkko Härkönen,Pirkko Härkönen +8 more
TL;DR: The results suggest that FGF-8, which is expressed by a great proportion of malignant breast and prostate tumors, may, among other factors, also be involved in the formation of osteosclerotic bone metastases.
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8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes
Elena Belloni,Maurizio Trubia,Patrizia Gasparini,Carla Micucci,Cinzia Tapinassi,Stefano Confalonieri,Paolo Nuciforo,Bruno Martino,Francesco Lo-Coco,Pier Giuseppe Pelicci,Pier Paolo Di Fiore +10 more
TL;DR: It is shown that both the TIF1–FGFR1 and FGFR1–TIF1 fusion proteins have the potential to be translated as a result of the translocation, lending support to the concept that there is a precise correlation between genotype and phenotype in this disease.
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ERK- and JNK-Dependent Signaling Pathways Contribute to Bombyx mori Nucleopolyhedrovirus Infection
TL;DR: Results indicate that the activation of MAPK signaling pathways is required for efficient infection by BmNPV.
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Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implications
TL;DR: Perturbations in the FGFR/FGF signaling are present in both inherited and malignant diseases, and the development of potent inhibitors targeting FGF/FGFR may provide new tools against disorders caused by FGF-FGFR alterations.
References
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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
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Protein modules and signalling networks
TL;DR: This work highlights conserved protein domains that act as key regulatory participants in many of these different signalling pathways in multicellular organisms.
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Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
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Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.