Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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Forced expression of hepatocyte‐specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis
Xinqiang Huang,Chundong Yu,Chengliu Jin,Chaofeng Yang,Rui Xie,Dongdong Cao,Fen Wang,Wallace L. McKeehan +7 more
TL;DR: It is proposed that FGF21 may delay development of adenomas through activation of resident hepatocyte FGFR4 at early times, but counteracts the delay by acceleration of progression to HCC through interaction with ectopic FGFR1 once it appears in hepatoma cells.
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Similarities and dissimilarities of branching and septation during lung development.
TL;DR: Current knowledge of key molecules influencing branching and septation is reviewed and the molecular similarities and dissimilarities between the two processes of airspace enlargement are discussed.
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Non-canonical fibroblast growth factor signalling in angiogenesis
TL;DR: Recent findings related to non-canonical FGF signalling are discussed with emphasis on the endothelial biology and angiogenesis and gangliosides are implicated as a co-receptor system of FGFs.
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Fibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the Wnt signaling pathway.
TL;DR: The findings suggest that FGF2 stimulation of osteoblast differentiation and bone formation is mediated in part by modulating the Wnt pathway.
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Immunolocalization of fibroblast growth factor-1 (FGF-1), its receptor (FGFR-1), and fibroblast-specific protein-1 (FSP-1) in inflammatory renal disease
Michele Rossini,Boonyarit Cheunsuchon,Ellen Donnert,Li-Jun Ma,James W. Thomas,Eric G. Neilson,Agnes B. Fogo +6 more
TL;DR: The expression of FGF-1 and FGFR-1 in infiltrating lymphocytes and macrophages, and of FGFR -1 in tubules, is supportive, but does not prove causality, of the possibility that F GF-1 might have both autocrine and paracrine functions in renal inflammation.
References
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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
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Protein modules and signalling networks
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Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
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Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.