Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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Evaluation of the fibroblast growth factor system as a potential target for therapy in human prostate cancer
Bharat Gowardhan,David Douglas,ME Mathers,Arthur B. McKie,Stuart McCracken,Craig N. Robson,Hing Y. Leung +6 more
TL;DR: The model of FGF system as valid target for therapy in CaP is supported and synergistic effects on in vitro cell growth (proliferation and colony formation) by combining sFGFR expression and treatment with either Paclitaxel (Taxol®) or γ-irradiation are confirmed.
Journal ArticleDOI
Oxidants in receptor tyrosine kinase signal transduction pathways.
Mutay Aslan,Tomris Ozben +1 more
TL;DR: A review examines the mechanisms of growth factor-induced generation of ROS and their roles in specific receptor tyrosine kinase signaling pathways and suggests that reactive oxygen species (ROS) such as O(2).- and H( 2)O(2) function as mitogenic mediators of activated growth-factor receptor signaling.
Journal ArticleDOI
Generation of FGF reporter transgenic zebrafish and their utility in chemical screens
TL;DR: The generation of transgenic reporter zebrafish lines has allowed direct visualization of FGF signalling within the developing embryo and provided a tool to screen for specific compounds that can distinguish between two conserved members of the RTK family.
Journal ArticleDOI
YKL-40, a Marker of Simian Immunodeficiency Virus Encephalitis, Modulates the Biological Activity of Basic Fibroblast Growth Factor
Dafna Bonneh-Barkay,Stephanie J. Bissel,Gouji Wang,Kenneth N. Fish,Georgina C. B. Nicholl,Samuel W. Darko,Rafael Medina-Flores,Michael Murphey-Corb,Premeela A. Rajakumar,Julia Nyaundi,John W. Mellors,Robert Bowser,Clayton A. Wiley +12 more
TL;DR: It is demonstrated that during lentiviral encephalitis, YKL-40 may interfere with the biological activity of bFGF and potentially of other heparin-binding growth factors and chemokines that can affect neuronal function or survival.
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Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury.
TL;DR: The data indicate that selective upregulation of FGF-2 in adult RGCs stimulates axon regrowth within the optic nerve, an environment that is highly inhibitory for regeneration.
References
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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
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Protein modules and signalling networks
TL;DR: This work highlights conserved protein domains that act as key regulatory participants in many of these different signalling pathways in multicellular organisms.
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Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
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Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.