Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
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Regulation and maintenance of vascular tone and patency in cardiovascular health and disease.
TL;DR: This special issue of highlights the latest findings related to the role of endothelial dysfunction in cardiovascular disease and offers unique insights into the mechanisms underlying diabetes-induced changes in endothelial biology and highlights specific pathways that could be novel therapeutic targets.
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Targeting Fibroblast Growth Factor Pathways in Prostate Cancer
TL;DR: Preliminary results from these trials suggest that FGF pathway inhibition represents a promising new strategy to treat castrate-resistant disease.
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Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.
Israel S. Fernández,Pedro Cuevas,Javier Angulo,Pilar López-Navajas,Angeles Canales-Mayordomo,Rocío González-Corrochano,Rosa M. Lozano,Serafin Valverde,Jesús Jiménez-Barbero,Antonio Romero,Guillermo Giménez-Gallego +10 more
TL;DR: Gentisic acid was used as a lead to identify additional compounds with better inhibitory characteristics generating a new chemical class of fibroblast growth factor inhibitors that includes the agent responsible for alkaptonuria, and evidence was obtained that this group of inhibitors may be of interest to treat cancer and angiogenesis-dependent diseases.
Journal ArticleDOI
A Phase I, Open-Label, Multicenter, Dose-escalation Study of the Oral Selective FGFR Inhibitor Debio 1347 in Patients with Advanced Solid Tumors Harboring FGFR Gene Alterations.
Martin H. Voss,Cinta Hierro,Rebecca S. Heist,James M. Cleary,Funda Meric-Bernstam,Josep Tabernero,Filip Janku,Leena Gandhi,A. John Iafrate,Darrell R. Borger,Nobuya Ishii,Youyou Hu,Yulia Kirpicheva,Valerie Nicolas-Metral,Anna Pokorska-Bocci,Anne Vaslin Chessex,Claudio Zanna,Keith T. Flaherty,José Baselga,José Baselga +19 more
TL;DR: Preliminary efficacy was encouraging and tolerability acceptable up to 80 mg/day, which is now used in an extension part of the study and dermatologic toxicity became sometimes dose limiting beyond the DLT period at ≥80 mg/ day.
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The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.
Hans-Dietmar Beer,Michaela Bittner,Gisela Niklaus,Christine Munding,Nicole Max,Andreas Goppelt,Sabine Werner +6 more
TL;DR: It is suggested that upregulation of FGF-BP expression after injury stimulates FGF activity at the wound site, thus enhancing the process of epithelial repair, and providing evidence for a role of this protein in epithelial Repair processes.
References
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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
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Protein modules and signalling networks
TL;DR: This work highlights conserved protein domains that act as key regulatory participants in many of these different signalling pathways in multicellular organisms.
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Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
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Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.