Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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Improved tumor-targeting drug delivery and therapeutic efficacy by cationic liposome modified with truncated bFGF peptide.
Xiang Chen,Xianhuo Wang,Yongsheng Wang,Li Yang,Jia Hu,Wenjing Xiao,Afu Fu,Lulu Cai,Xia Li,Xia Ye,Ya-lin Liu,Wenshuang Wu,Ximing Shao,Yong-qiu Mao,Yuquan Wei,Lijuan Chen +15 more
TL;DR: Treatment of tumor-bearing mice with a truncated human basic fibroblast growth factor peptide and a FGFR-mediated drug delivery system may provide a new treatment strategy for tumors which overexpress FGFRs are suggested.
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Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis.
Yongshun Lin,Guoqin Liu,Yongyou Zhang,Ya-Ping Hu,Kai Yu,Chunhong Lin,Kerstin McKeehan,Jim W. Xuan,David M. Ornitz,Michael M. Shen,Norman M. Greenberg,Wallace L. McKeehan,Fen Wang +12 more
TL;DR: Fgfr2cn prostates provide a useful animal model for scrutinizing molecular mechanisms by which androgens regulate prostate growth, homeostasis and function, and may yield clues as to how advanced-tumor prostate cells escape strict androgen regulations.
Journal ArticleDOI
FGF signaling in gastrulation and neural development in Nematostella vectensis , an anthozoan cnidarian
TL;DR: A conserved role for FGF signaling molecules in coordinating both gastrulation and neural induction that predates the Cambrian explosion and the origins of the Bilateria is suggested.
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Independent Repression of Bile Acid Synthesis and Activation of c-Jun N-terminal Kinase (JNK) by Activated Hepatocyte Fibroblast Growth Factor Receptor 4 (FGFR4) and Bile Acids
Chundong Yu,Chundong Yu,Fen Wang,Chengliu Jin,Xinqiang Huang,Wallace L. McKeehan,Wallace L. McKeehan +6 more
TL;DR: It is confirmed that hepatocyte FGFR4 regulates bile acid synthesis by repression of Cyp7a1 expression, and may contribute to the repression of bile Acid synthesis through JNK signaling but is not required for activation of JNK signaled by bile acids.
Journal ArticleDOI
A Comprehensive Guide to the MAGE Family of Ubiquitin Ligases
Anna K. Lee,Patrick Ryan Potts +1 more
TL;DR: A comprehensive guide to MAGEs is presented highlighting the molecular mechanisms of MRLs and their physiological roles in germ cell and neural development, oncogenic functions in cancer, and potential as therapeutic targets in disease.
References
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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
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Protein modules and signalling networks
TL;DR: This work highlights conserved protein domains that act as key regulatory participants in many of these different signalling pathways in multicellular organisms.
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Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
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Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.