Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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FGFR3 and Tp53 mutations in T1G3 transitional bladder carcinomas: independent distribution and lack of association with prognosis.
Silvia Hernández,Elena Lopez-Knowles,Josep Lloreta,Manolis Kogevinas,Roberto Jaramillo,Alex Amoros,Adonina Tardón,Reina García-Closas,Consol Serra,Alfredo Carrato,Núria Malats,Francisco X. Real +11 more
TL;DR: Molecular features of FGFR3 and Tp53 mutations support the notion that T1G3 tumors are at the crossroads of the two main molecular pathways proposed for bladder cancer development and progression.
Journal ArticleDOI
FGF signaling regulates expression of Tbx2, Erm, Pea3, and Pax3 in the early nasal region.
Nicole Firnberg,Annette Neubüser +1 more
TL;DR: Tbx2, Erm, Pea3, and Pax3 are identified as downstream targets of FGF signaling in the facial area and suggest that these genes may mediate some of the effects of F GF8 during development of the nasal region.
Journal ArticleDOI
Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies
Mohamed R. Akl,Poonam Nagpal,Nehad M. Ayoub,Betty Tai,Sathyen A. Prabhu,Catherine M. Capac,Matthew Gliksman,Andre Goy,K. Stephen Suh +8 more
TL;DR: This review focuses on the prognostic significance of FGF2 in cancer with emphasis on therapeutic intervention strategies for solid and hematological malignancies.
Journal ArticleDOI
Requirement of fibroblast growth factor 10 in development of white adipose tissue
Hiroshi Sakaue,Morichika Konishi,Wataru Ogawa,Toshiyuki Asaki,Toshiyuki Mori,Masahiro Yamasaki,Masafumi Takata,Hikaru Ueno,Shigeaki Kato,Masato Kasuga,Nobuyuki Itoh +10 more
TL;DR: FGF10 plays an important role in adipogenesis, at least partly by contributing to the expression of C/EBPbeta through an autocrine/paracrine mechanism.
Book ChapterDOI
Signaling, Internalization, and Intracellular Activity of Fibroblast Growth Factor
A. Więdłocha,V. Sørensen +1 more
TL;DR: The role of FGF internalization and the intracellular activity of some FGFs are discussed in the context of the known signaling induced by FGF.
References
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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
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Thalidomide is an inhibitor of angiogenesis.
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Journal ArticleDOI
Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.