Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
More filters
Journal ArticleDOI
Growth factors and cytokines in wound healing.
TL;DR: A review of the specific roles of these growth factors and cytokines during wound healing can be found in this article, where patients are treated by three growth factors: PDGF-BB, bFGF, and GM-CSF.
Journal ArticleDOI
Fibroblast growth factors
David M. Ornitz,Nobuyuki Itoh +1 more
TL;DR: A subset of the FGF family, expressed in adult tissue, is important for neuronal signal transduction in the central and peripheral nervous systems.
Journal ArticleDOI
FGF-21 as a novel metabolic regulator
Alexei Kharitonenkov,Tatiyana L. Shiyanova,Anja Koester,Amy M. Ford,Radmila Micanovic,Elizabeth Galbreath,George E. Sandusky,Lisa Janine Hammond,Julie S. Moyers,Owens Rebecca Anne,Jesper Gromada,Joseph T. Brozinick,Eric D. Hawkins,Victor J. Wroblewski,De Shan Li,Farrokh Mehrbod,S. Richard Jaskunas,Armen B. Shanafelt +17 more
TL;DR: It is concluded that FGF-21, which was discovered to be a potent regulator of glucose uptake in mouse 3T3-L1 and primary human adipocytes, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.
Journal ArticleDOI
The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TL;DR: Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.
Journal ArticleDOI
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
Xiuqin Zhang,Omar A. Ibrahimi,Shaun K. Olsen,Hisashi Umemori,Moosa Mohammadi,David M. Ornitz +5 more
TL;DR: This study completes the mitogenesis-based comparison of receptor specificity of the entire FGF family under standard conditions and should help in interpreting and predicting in vivo biological activity.
References
More filters
Journal ArticleDOI
Analysis of Putative Heparin-binding Domains of Fibroblast Growth Factor-1: USING SITE-DIRECTED MUTAGENESIS AND PEPTIDE ANALOGUES (∗)
TL;DR: The contribution of individual basic amino acids within three putative consensus sequences for heparin binding of fibroblast growth factor-1 have been examined by site-directed mutagenesis as discussed by the authors.
Journal ArticleDOI
Gene expression of fibroblast growth factor receptors in the tissues of human gliomas and meningiomas.
Jun A. Takahashi,Hiroshi Suzui,Yosiko Yasuda,Nobuyuki Ito,Mitsuhiro Ohta,Michael Jaye,Manabu Fukumoto,Yoshifumi Oda,Haruhiko Kikuchi,Masakazu Hatanaka +9 more
TL;DR: Northern blot analysis showed transcripts of two types of the fibroblast growth factor (FGF) receptor genes, flg and bek, in almost all the tissues samples of 18 human gliomas and 22 human meningiomas, which produced abundant basic and/or acidic FGF.
Journal ArticleDOI
Biological equivalence of natural bovine and recombinant human alpha-endothelial cell growth factors.
TL;DR: Recombinant human mitogen has the same biological potency as the bovine brain-derived material and the interaction between recombinant ECGF and heparin was studied.
Journal ArticleDOI
Nucleolar association of fibroblast growth factor 3 via specific sequence motifs has inhibitory effects on cell growth.
TL;DR: Nuclear import and nucleolar association of FGF3 are determined by the concerted interaction of several distinct motifs, and the exclusive production of the nuclear isoform can inhibit DNA synthesis and cell proliferation.
Journal ArticleDOI
Reductive methylation of lysine residues in acidic fibroblast growth factor: effect on mitogenic activity and heparin affinity
J W Harper,R R Lobb +1 more
TL;DR: The results indicate that in aF GF, Lys-118 plays an important role in heparin binding and suggest that this residue and its local environment are involved in the interaction of aFGF with both hepar in and its cell surface receptor.