Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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Fibroblast Growth Factor Receptor Family Members as Prognostic Biomarkers in Head and Neck Squamous Cell Carcinoma: A Systematic Review
Norbertus A. Ipenburg,Koos Koole,K. Seng Liem,Pauline M. W. van Kempen,Ron Koole,Paul J. van Diest,Robert J.J. van Es,Stefan M. Willems,Stefan M. Willems +8 more
TL;DR: Evidence was found for prognostic value of FGFR1 expression in cancer-associated fibroblasts in HNSCC and the need for future well-conducted prognostic studies is emphasized.
Journal ArticleDOI
Associated expressions of FGFR-2 and FGFR-3: from mouse mammary gland physiology to human breast cancer
Juan P. Cerliani,Silvia Vanzulli,Cecilia Pérez Piñero,Maria Cecilia Bottino,Ana Sahores,Myriam Nuñez,Romina Varchetta,Rubén Martins,Eduardo Zeitlin,Stephen M. Hewitt,Alfredo A. Molinolo,Claudia Lanari,Caroline A. Lamb +12 more
TL;DR: It is concluded that FGFR-2 and -3 may be mechanistically linked and can be potential targets for treatment of estrogen receptor-positive breast cancer patients.
Journal ArticleDOI
Long-term safety of intramuscular gene transfer of non-viral FGF1 for peripheral artery disease.
A. Niebuhr,Timothy D. Henry,Jo Anne Goldman,Iris Baumgartner,E. Van Belle,J. Gerss,Alan T. Hirsch,Sigrid Nikol +7 more
TL;DR: At 3 years, in 93 patients included in this registry, there was no increase in retinopathy or renal dysfunction associated with delivery of this angiogenic factor, and there was also no difference in the number of strokes, MI or deaths for NV1FGF versus placebo.
Journal ArticleDOI
FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression
Ekele Ikpegbu,Ekele Ikpegbu,Lena P. Basta,Dylan N. Clements,Robert Fleming,Tonia L. Vincent,David J. Buttle,Andrew A. Pitsillides,Katherine Staines,Colin Farquharson +9 more
TL;DR: The data suggests that FGF‐2 promotes osteocytogenesis through increased E11 expression and further studies will identify if this regulatory pathway is essential for bone development and maintenance in health and disease.
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The structural biology of growth factor receptor activation.
TL;DR: It is proposed that, in general, weak binary interactions between growth factor and individual domains of receptors are enhanced by cooperative interactions with further receptor domains, and sometimes other components like heparan, to give rise to specific multi-protein/domain complexes.
References
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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
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Protein modules and signalling networks
TL;DR: This work highlights conserved protein domains that act as key regulatory participants in many of these different signalling pathways in multicellular organisms.
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Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
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Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.