Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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Journal ArticleDOI
Amniotic cells share clusters of differentiation of fibroblasts and keratinocytes, influencing their ability to proliferate and aid in wound healing while impairing their angiogenesis capability.
Diana Kitala,Agnieszka Klama-Baryła,Wojciech Łabuś,Marek Ples,Marcelina Misiuga,Małgorzata Kraut,Micha Szapski,Rafa Bobiński,Anna Pielesz,Marek J. Łos,Marek Kucharzewski +10 more
TL;DR: It was shown that adding amniotic cells to both keratinocytes and fibroblast cultures accelerates directional migration by ≥ 40% and it was demonstrated that humanAmniotic membrane-derived mesenchymal stem cells (hAMMSCs) share amniotics proteins with skin cells.
Journal ArticleDOI
Ascorbic acid rescues cardiomyocyte development in Fgfr1(-/-) murine embryonic stem cells.
Elisabetta Crescini,Laura Gualandi,Daniela Uberti,Chiara Prandelli,Marco Presta,Patrizia Dell'Era +5 more
TL;DR: Only the reduced form of vitC, l-ascorbic acid, was able to recover beating cell differentiation in Fgfr1(-/-) mESC, thus implicating HIF-1α modulation in F gfr1-dependent cardiomyogenesis.
Journal ArticleDOI
A novel Fibroblast Growth Factor Receptor family member promotes neuronal outgrowth and synaptic plasticity in Aplysia
TL;DR: ApLRRTK is unveiled, a neuronal cell-surface protein recently identified in Aplysia, as the first member of the FGFRs family deprived of Ig-like domains that instead contains extracellular LRR domains, and reveals an unprecedented mechanism of FGFR gene diversification in primeval central nervous systems.
Book ChapterDOI
The Enterokine Fibroblast Growth Factor 15/19 in Bile Acid Metabolism.
TL;DR: Recently engineered FGF19 analogues have been recently synthetized, with fully retained BA regulatory activity but without intrinsic pro-tumoral action, thus opening bona fide novel pharmacological strategy for the treatment of gut-liver axis diseases.
Journal ArticleDOI
Fibroblast growth factor 2 regulates bone sialoprotein gene transcription in human breast cancer cells.
Zhengyang Li,Zhitao Wang,Li Yang,Xinyue Li,Yoko Sasaki,Shuang Wang,Shuang Wang,Shouta Araki,Masaru Mezawa,Hideki Takai,Youhei Nakayama,Yorimasa Ogata +11 more
TL;DR: These studies demonstrate that FGF2 stimulates BSP transcription in MCF7 human breast cancer cells by targeting the AP1 and CRE2 elements in the human BSP gene promoter.
References
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Journal ArticleDOI
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David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.