Fibroblast growth factors, their receptors and signaling.
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TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
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Growth factors and cytokines in wound healing.
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Fibroblast growth factors
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FGF-21 as a novel metabolic regulator
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TL;DR: It is concluded that FGF-21, which was discovered to be a potent regulator of glucose uptake in mouse 3T3-L1 and primary human adipocytes, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.
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The Fibroblast Growth Factor signaling pathway
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Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
Xiuqin Zhang,Omar A. Ibrahimi,Shaun K. Olsen,Hisashi Umemori,Moosa Mohammadi,David M. Ornitz +5 more
TL;DR: This study completes the mitogenesis-based comparison of receptor specificity of the entire FGF family under standard conditions and should help in interpreting and predicting in vivo biological activity.
References
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Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis.
Kevin G. Peters,Jacky Marie,Jacky Marie,Emily Wilson,Harlan E. Ives,Jaime Escobedo,Mercedita Del Rosario,Daniel Mirda,Lewis T. Williams +8 more
TL;DR: Findings show that a point mutation in the FGF receptor selectively eliminates activation of PLCγ and that neither Ca2+ mobilization nor Ptdlns hydrolysis are required for FGF-induced mitogenesis.
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Fibroblast growth factor 2 control of vascular tone.
Ming Zhou,Roy L. Sutliff,Richard J. Paul,John N. Lorenz,James B. Hoying,Christian C. Haudenschild,Moying Yin,J. Douglas Coffin,Ling Kong,Evangelia G. Kranias,Wusheng Luo,Gregory P. Boivin,John J. Duffy,Sharon A. Pawlowski,Thomas Doetschman +14 more
TL;DR: It is shown that a well-known growth factor, FCF2, long thought to be involved in many developmental and homeostatic processes, including growth of the tissue layers of vessel walls, functions in vascular tone control.
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Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction.
TL;DR: It is demonstrated that autophosphorylation on tyrosines 653 and 654 is important for activation of tyrosine kinase activity of FGFR1 and is therefore essential forFGFR1-mediated biological responses.
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Diverse forms of a receptor for acidic and basic fibroblast growth factors.
TL;DR: The first immunoglobulinlike domain of the three-domain form may have a function other than binding of acidic and basic FGF.
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Three-dimensional structures of acidic and basic fibroblast growth factors.
Xiaotian Zhu,H. Komiya,Arthur J. Chirino,Salem Faham,Gary M. Fox,Tsutomu Arakawa,Barbara T. Hsu,Douglas C. Rees +7 more
TL;DR: Three-dimensional structures of two members of the fibroblast growth factor (FGF) family of proteins, bovine acidic FGF and human basic FGF, have been crystallographically determined and the locations of sequences implicated in receptor and heparin binding by FGF are presented.