Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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Hydroxyurea-induced global transcriptional suppression in mouse ES cells
Peng Cui,Qiang Lin,Qiang Lin,Chengqi Xin,Chengqi Xin,Lu Han,Lili An,Yulan Wang,Zhishang Hu,Feng Ding,Lingfang Zhang,Lingfang Zhang,Songnian Hu,Haiying Hang,Jun Yu +14 more
TL;DR: The global transcriptional activity is significantly suppressed as cells are exposed to HU treatment and alters multiple key cellular pathways, including cell cycle, apoptosis and DNAs, which suggests that high-throughput sequencing technology provides a powerful tool to study mechanisms of clinical drugs at the cellular level.
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Suramin blocks interaction between human FGF1 and FGFR2 D2 domain and reduces downstream signaling activity.
TL;DR: The results indicate that suramin blocks the interaction between hFGF1 and FGFR2 D2, which will be useful for the development of new antimitogenic activity drugs.
Journal ArticleDOI
Discovery and Characterization of a High-Affinity Small Peptide Ligand, H1, Targeting FGFR2IIIc for Skin Wound Healing
Ying Zhao,Qiang Wang,Yuan Jin,Yadan Li,Changjun Nie,Peipei Huang,Zhixin Li,Bihui Zhang,Zijian Su,An Hong,Xiaojia Chen +10 more
TL;DR: The discovery of a novel small peptide targeting fibroblast growth factor receptor 2 IIIc (FGFR2IIIc) as a potential candidate for skin wound healing and shows potential as a wound healing agent is reported.
Journal ArticleDOI
Functional FGFR4 Gly388Arg polymorphism contributes to cancer susceptibility: Evidence from meta-analysis.
Si-Wei Xiong,Jianqun Ma,Fen Feng,Wen Fu,Shan-Rong Shu,Tianjiao Ma,Caixia Wu,Guochang Liu,Jinhong Zhu +8 more
TL;DR: A meta-analysis demonstrates the FGFR rs351855 G>A polymorphism is associated with increased cancer risk and suggests it could potentially serve as a chemotherapeutic target or biomarker to screen high-risk individuals.
Book ChapterDOI
Proteases and Their Cognate Inhibitors of the Serine and Metalloprotease Subclasses, in Testicular Physiology
TL;DR: The testis is a highly dynamic organ not only in the fetal stage but also during postnatal development and in adult life, and is composed of two major compartments: the interstitium with the steroidogenic Leydig cells, and the seminiferous tubules.
References
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Journal ArticleDOI
Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.