Fibroblast growth factors, their receptors and signaling.
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TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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Fibroblast Growth Factors and their Emerging Cancer-Related Aspects
TL;DR: Overexpression of FGFs and FGFRs has been correlated with advanced tumor forms, mainly prostate, mammary gland, bladder and renal cell carcinomas.
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Eruptive nevi in prostate cancer: is this a paraneoplastic phenomenon?
TL;DR: Eruptive nevi have occurred in patients with underlying hematological malignancies prior to and whilst on chemotherapy and after bullous eruptions and in patients following bullous disease, the reports of nevi occurring at healing sites suggests that local growth factor release such as fibroblast growth factor has a role in triggering nevus formation.
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The ORF 113 of Helicoverpa armigera single nucleopolyhedrovirus encodes a functional fibroblast growth factor
TL;DR: HearNPV vFGF had strong affinity to heparin, a property important for FGF signaling via an FGF receptor, which coordinated to the chemotatic activity analysis.
Dissertation
Polymers and protein-conjugates for tissue engineering
TL;DR: Diblock co-polymers with different molecular weight were synthesized and characterized with the goal of obtaining substances processable to mechanically stable scaffolds for in vivo or in vitro experiments and first steps were undertaken towards the in vivo evaluation of these polymers.
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Trimodal rescue of hind limb ischemia with growth factors, cells, and nanocarriers: fundamentals to clinical trials.
TL;DR: In this review, the basic mechanism through which growth factors exert their beneficial properties to rescue the ischemic limb is extensively discussed and clinical trials based on growth factor and stem cell therapy to treat critical limb ischemia are considered.
References
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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
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Protein modules and signalling networks
TL;DR: This work highlights conserved protein domains that act as key regulatory participants in many of these different signalling pathways in multicellular organisms.
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Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
Journal ArticleDOI
Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.