Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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Heparan Sulfate Domain Organization and Sulfation Modulate FGF-induced Cell Signaling
TL;DR: The results suggest that the effects of HS on FGF2 signaling are determined by both the structure of the highly sulfated domains and by the organization/availability of such domains within the HS chain, which underpin the need for regulation of HS biosynthesis in relation to control of growth factor-induced signaling pathways.
Journal ArticleDOI
FGF signaling in flies and worms: More and more relevant to vertebrate biology
Peng Huang,Michael J. Stern +1 more
TL;DR: Recent work has shown that the pleiotropies of these FGF receptors resemble those of their vertebrate counterparts, and, in many cases, serve as excellent models for understanding the fundamental molecular mechanisms controlling these events.
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An overview of the therapeutic potential of regenerative medicine in cutaneous wound healing.
Calver Pang,Amel Ibrahim,Neil W. Bulstrode,Neil W. Bulstrode,Patrizia Ferretti,Patrizia Ferretti +5 more
TL;DR: The global burden of disease associated with wounds is an increasingly significant public health concern and the challenge of overcoming current barriers associated with wound care requires innovative management techniques.
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Temporal and spatial expression of FGF ligands and receptors during Xenopus development.
TL;DR: This study constitutes the most comprehensive description of the temporal and spatial expression pattern of fGF ligands and receptors during vertebrate development to date and shows the transient nature of expression of several fgfs in a number of embryonic tissues.
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Expression of Basic Fibroblast Growth Factor Correlates with Resistance to Paclitaxel in Human Patient Tumors
TL;DR: A role of bFGF in paclitaxel resistance in human patient tumors is supported, and aFGF expression was a stronger predictor of paclitAXel resistance compared to Pgp, p53, or Bcl-2.
References
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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
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Protein modules and signalling networks
TL;DR: This work highlights conserved protein domains that act as key regulatory participants in many of these different signalling pathways in multicellular organisms.
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Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
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Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.