Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
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Growth factors and cytokines in wound healing.
TL;DR: A review of the specific roles of these growth factors and cytokines during wound healing can be found in this article, where patients are treated by three growth factors: PDGF-BB, bFGF, and GM-CSF.
Journal ArticleDOI
Fibroblast growth factors
David M. Ornitz,Nobuyuki Itoh +1 more
TL;DR: A subset of the FGF family, expressed in adult tissue, is important for neuronal signal transduction in the central and peripheral nervous systems.
Journal ArticleDOI
FGF-21 as a novel metabolic regulator
Alexei Kharitonenkov,Tatiyana L. Shiyanova,Anja Koester,Amy M. Ford,Radmila Micanovic,Elizabeth Galbreath,George E. Sandusky,Lisa Janine Hammond,Julie S. Moyers,Owens Rebecca Anne,Jesper Gromada,Joseph T. Brozinick,Eric D. Hawkins,Victor J. Wroblewski,De Shan Li,Farrokh Mehrbod,S. Richard Jaskunas,Armen B. Shanafelt +17 more
TL;DR: It is concluded that FGF-21, which was discovered to be a potent regulator of glucose uptake in mouse 3T3-L1 and primary human adipocytes, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.
Journal ArticleDOI
The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TL;DR: Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.
Journal ArticleDOI
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
Xiuqin Zhang,Omar A. Ibrahimi,Shaun K. Olsen,Hisashi Umemori,Moosa Mohammadi,David M. Ornitz +5 more
TL;DR: This study completes the mitogenesis-based comparison of receptor specificity of the entire FGF family under standard conditions and should help in interpreting and predicting in vivo biological activity.
References
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Journal ArticleDOI
Specific binding of basic fibroblast growth factor to basement membrane-like structures and to purified heparan sulfate proteoglycan of the EHS tumor.
Marc Vigny,M. P. Ollier-Hartmann,Marc Lavigne,N.A. Fayein,J.C. Jeanny,Maryvonne Laurent,Yves Courtois +6 more
TL;DR: Investigation of the binding of iodinated basic fibroblast growth factor to low‐density heparan sulfate proteoglycan purified from the Engelbreth Holm Swarm sarcoma found that it could be strongly inhibited by heparin and was displaced by an excess of unlabeled factor and completely suppressed after heparitinase and hepar inase treatments.
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Structure and Expression of the mRNA Encoding a Novel Fibroblast Growth Factor, FGF-18
Norihiko Ohbayashi,Masamitsu Hoshikawa,Sachie Kimura,Masahiro Yamasaki,Shigeyuki Fukui,Nobuyuki Itoh +5 more
TL;DR: The present results indicate that FGF-18 is a unique secreted signaling molecule in the adult lung and developing tissues.
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Profound ligand-independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II.
TL;DR: The data suggest that the molecular effect of the TDII activation loop mutation is to mimic the conformational changes that activate the tyrosine kinase domain, which are normally initiated by ligand binding and autophosphorylation.
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Structure and Expression of a Novel Member, FGF-16, of the Fibroblast Growth Factor Family ☆
Ayumi Miyake,Miorichika Konishi,Francis Hall Martin,Natasha A. Hernday,Keiichi Ozaki,Shigenori Yamamoto,Tadahisa Mikami,Tsutomu Arakawa,Nobuyuki Itoh +8 more
TL;DR: In rat embryos, FGF-16 mRNA was predominantly expressed in the brown adipose tissue, however, the expression decreased greatly after birth, indicating that F GF-16 in embryos might play a role in development of the brown fat tissue.
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The int-2 proto-oncogene is responsible for induction of the inner ear
TL;DR: Direct evidence is provided by showing that the formation of the otic vesicle is inhibited by antisense oligonucleotides targeted to the secreted form of int-2, and by antibodies againstint-2 oncoproteins, and basic FGF (bFGF) can mimic the inductive signal in the absence of the rhombencephalon.