Fibroblast growth factors, their receptors and signaling.
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TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
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Platelet-Derived Growth Factor-BB–Induced Human Smooth Muscle Cell Proliferation Depends on Basic FGF Release and FGFR-1 Activation
Esther Millette,Bernhard H. Rauch,Olivier D. Defawe,Richard D. Kenagy,Guenter Daum,Alexander W. Clowes +5 more
TL;DR: The results provide support for a novel mechanism by which PDGF-BB induces the release of bFGF and activation of FGFR-1 followed by the sustained activation of ERK and proliferation of human SMCs.
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Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours
Brittany C. Parker,Brittany C. Parker,Manon Engels,Manon Engels,Matti Annala,Wei Zhang,Wei Zhang +6 more
TL;DR: The ability to exploit the unique targetability of FGFR fusions proves that FGFR‐derived therapies could have a promising future in cancer therapeutics, and understanding the diverse mechanisms ofFGFR fusion formation and their oncogenic potential will shed light on the impact of FG FR‐derived therapy in the future.
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Surgery, wound healing, and metastasis: recent insights and clinical implications.
TL;DR: In depth knowledge of how surgical intervention alters the tumour-host-metastasis communicating ecosystems could have important implications for clinical decision making in patients with synchronous metastatic disease and for the design and timing of multimodality treatment strategies.
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Fibroblast growth factor-2 is expressed by the bovine uterus and stimulates interferon-τ production in bovine trophectoderm
Donna D. Michael,I M Alvarez,Olga M. Ocón,Anne M. Powell,Neil C. Talbot,Sally E. Johnson,Alan D. Ealy +6 more
TL;DR: FGF-2 is present in the uterine lumen during early pregnancy and increases IFNT mRNA and protein abundance in trophectoderm, which suggests that this uterine-derived factor plays an active role in regulating the establishment and maintenance of pregnancy in ruminants.
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Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys.
Haijun D. Sun,Maria Malabunga,James R. Tonra,Roberto DiRenzo,Francine E. Carrick,Huiyuan Zheng,Hans-Rudolf Berthoud,Owen P. McGuinness,Juqun Shen,Peter Bohlen,Rudolph L. Leibel,Paul Kussie +11 more
TL;DR: The data suggest that FGF signaling through FGFR1c may play a physiological role in hypothalamic feeding circuit and that blocking it leads to hypophagia and weight loss.
References
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