Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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Growth factors and cytokines in wound healing.
TL;DR: A review of the specific roles of these growth factors and cytokines during wound healing can be found in this article, where patients are treated by three growth factors: PDGF-BB, bFGF, and GM-CSF.
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Fibroblast growth factors
David M. Ornitz,Nobuyuki Itoh +1 more
TL;DR: A subset of the FGF family, expressed in adult tissue, is important for neuronal signal transduction in the central and peripheral nervous systems.
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FGF-21 as a novel metabolic regulator
Alexei Kharitonenkov,Tatiyana L. Shiyanova,Anja Koester,Amy M. Ford,Radmila Micanovic,Elizabeth Galbreath,George E. Sandusky,Lisa Janine Hammond,Julie S. Moyers,Owens Rebecca Anne,Jesper Gromada,Joseph T. Brozinick,Eric D. Hawkins,Victor J. Wroblewski,De Shan Li,Farrokh Mehrbod,S. Richard Jaskunas,Armen B. Shanafelt +17 more
TL;DR: It is concluded that FGF-21, which was discovered to be a potent regulator of glucose uptake in mouse 3T3-L1 and primary human adipocytes, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.
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The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TL;DR: Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.
Journal ArticleDOI
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
Xiuqin Zhang,Omar A. Ibrahimi,Shaun K. Olsen,Hisashi Umemori,Moosa Mohammadi,David M. Ornitz +5 more
TL;DR: This study completes the mitogenesis-based comparison of receptor specificity of the entire FGF family under standard conditions and should help in interpreting and predicting in vivo biological activity.
References
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Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity.
Olli Saksela,Daniel B. Rifkin +1 more
TL;DR: It is proposed that this plasminogen activator-mediated proteolysis provides a mechanism for the release of biologically active bF GF-HSPG complexes from the extracellular matrix and that bFGF release can be regulated by the balance between factors affecting the pericellular proteolytic activity.
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Salvage of infarcted myocardium by angiogenic action of basic fibroblast growth factor.
Atsuko Yanagisawa-Miwa,Yasumi Uchida,Fumitaka Nakamura,Takanobu Tomaru,Hideaki Kido,Takeshi Kamijo,Tsuneaki Sugimoto,Kazuhiko Kaji,Masanori Utsuyama,Chieri Kurashima,Hideki Ito +10 more
TL;DR: In a canine experimental myocardial infarct model, intracoronary injection of basic fibroblast growth factor (bFGF) improved cardiac systolic function and reducedinfarct size, suggesting the angiogenic action of bFGF might lead to a reduction in infarCT size.
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Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis.
Mark D. Hulett,Craig Freeman,Brenton James Hamdorf,Rohan T. Baker,Matthew J. Harris,Christopher R. Parish +5 more
TL;DR: The cDNA sequence of the human platelet enzyme is reported, which encodes a unique protein of 543 amino acids, and the identification of highly homologous sequences in activated mouse T cells and in a highly metastatic rat adenocarcinoma.
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Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis
TL;DR: Results identify perlecan as a major candidate for a bFGF low affinity, accessory receptor and an angiogenic modulator.
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An essential heparin-binding domain in the fibroblast growth factor receptor kinase
TL;DR: The results indicate that the FGF receptor is a ternary complex of heparan sulfate proteoglycan, tyrosine kinase transmembrane glycoprotein, and ligand.