Fibroblast growth factors, their receptors and signaling.
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TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
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Polymorphism of FGFR4 in cancer development and sensitivity to cisplatin and radiation in head and neck cancer.
TL;DR: A marker is identified that predicts the risk to develop HNSCC and possibly the sensitivity to cisplatin as well as a novel mutation in the FGFR4 gene.
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FGFR4 Gly388Arg polymorphism may affect the clinical stage of patients with lung cancer by modulating the transcriptional profile of normal lung
Felicia S. Falvella,Elisa Frullanti,Antonella Galvan,Monica Spinola,Sara Noci,Loris De Cecco,Mario Nosotti,Luigi Santambrogio,Matteo Incarbone,Marco Alloisio,Elisa Calabrò,Ugo Pastorino,Vidar Skaug,Aage Haugen,Emanuela Taioli,Tommaso A. Dragani +15 more
TL;DR: Findings confirm the significant association of theFGFR4 Gly388Arg polymorphism with clinical stage and overall survival in an Italian lung ADCA population and demonstrate a FGFR4 genotype‐dependent transcriptional profile present in normal lung tissue.
Journal ArticleDOI
Heparin modulates the mitogenic activity of fibroblast growth factor by inducing dimerization of its receptor. a 3D view by using NMR
Lidia Nieto,Ángeles Canales,Israel S. Fernández,Elena Santillana,Rocío González-Corrochano,Mariano Redondo-Horcajo,F. Javier Cañada,Pedro M. Nieto,Manuel Martín-Lomas,Guillermo Giménez-Gallego,Jesús Jiménez-Barbero +10 more
TL;DR: It is reported that the simultaneous presence of FGF and the GAG is not an essential requisite for this event to take place, and preincubation with heparin (just before FGF addition) of cells lacking heparan sulfate produced an enhancing effect equivalent to that observed when the G AG and the protein are simultaneously added.
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GPC5 Gene and Its Related Pathways in Lung Cancer
TL;DR: Reduction of expression of GPC5 may lead to the development of lung cancer, suggesting that this gene normally functions as a tumor suppressor.
Journal ArticleDOI
FGFR4 Gly388Arg polymorphism contributes to prostate cancer development and progression: A meta-analysis of 2618 cases and 2305 controls
TL;DR: The evidence that FGFR4 Gly388Arg polymorphism was associated with an increased risk of prostate cancer development and progression was shown, suggesting that FG FR4 Gly 388 Arg polymorphism could be a marker for prostate cancerdevelopment and progression.
References
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David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.