Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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epithelial cells development via enhancements in proliferation and function of thymic Keratinocyte growth factor (KGF) enhances postnatal T-cell
Andrei V. Gudkov,Yousuke Takahama,Werner Krenger,Bruce R. Blazar,Georg A. Holländer,Simona W. Rossi,Lukas T. Jeker,Tomoo Ueno,Sachiyo Kuse,Marcel P. Keller,Saulius Zuklys +10 more
Journal ArticleDOI
Regulation of bFGF-induced effects on rat aortic smooth muscle cells by β3-adrenergic receptors
Yingzi Chang,Lei Alena Dagat,Aisha Yusuf,Yusuf Zahriya,Kotryna Staputyte,E. Worley,Alex Holt,Natalie Canuteson,Vereena Messieha,Kasey Halila +9 more
TL;DR: In this paper , the authors explored the role of β3-adrenergic receptors (β3-ARs) in vascular injury-induced neointima formation by testing its effects on bFGF-induced vascular smooth muscle cell migration and proliferation.
Over-expression of fibroblast growth factor 5 (FGF5) in melanoma
TL;DR: In this article, the authors investigate the effect of FGF5 Uberexpression on malignen Melanomom cells in vitro using a Scratch Assay and an Invasion Assay.
Dissertation
PEA3 and ER81: Roles in Transformation and Mammary Gland Development
TL;DR: PEA3 appears to be a crucial effector in Ras and Neu mediated transformation, in addition to serving an important regulatory role of genes involved in cell motility and invasive tumor behaviour.
References
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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
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Protein modules and signalling networks
TL;DR: This work highlights conserved protein domains that act as key regulatory participants in many of these different signalling pathways in multicellular organisms.
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Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
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Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.