Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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Review paper The role of growth factors in pathogenesis of pancreatic cancer. Part II: Transforming growth factor beta (TGF- β), fibroblast growth factor (FGF), nerve growth factor (NGF)
TL;DR: Transforming growth factor beta may be one of the factors responsible for liver metastases, which contributes to local tumour progression and stimulates desmoplastic reaction in tumours, in clinical studies establishing the usefulness of TGF-β measurements in patients with pancreatic cancer.
Journal ArticleDOI
Gender-Specific Association Between FGFR4 Gly388Arg Gene Variants and Hypertension.
TL;DR: The FGFR4 Arg388 allele is associated with an increased risk of hypertension in Saudi female subjects and the lack of association in men needs to be further investigated.
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Genomic compartmentalization of gene families encoding core components of metazoan signaling systems
Howard Wong,Jung Soh,Paul M. K. Gordon,Tom Yu,Christoph Wilhelm Sensen,Edward J. Parr,Randal N. Johnston +6 more
TL;DR: This study centered on the distinct evolutionarily conserved metazoan signalling pathways that employ proteins in the receptor tyrosine kinase, WNT, hedgehog, NOTCH, Janus kinase/STAT, transforming growth factor beta, and nuclear hormone receptor protein families proposed that the genome can be subdivided into six genome-wide primary linkage groups (PLGs).
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FGFR4 c.1162G > A (p.Gly388Arg) Polymorphism Analysis in Turkish Patients with Retinoblastoma.
Demet Akdeniz Odemis,Seref Bugra Tuncer,Arash Adamnejad Ghafour,Khariga Jabbarli,Yasemin Gider,Betul Celik,Gozde Kuru Turkcan,Ozge Sukruoglu Erdogan,Seda Kilic Erciyas,Mukaddes Avsar,Rejin Kebudi,Sema Buyukkapu Bay,Samuray Tuncer,Hulya Yazici +13 more
TL;DR: In this article, the FGFR4 p.Gly388Arg allele frequency was found to be 50 percent common in the Turkish population in retinoblastoma patients with no RB1 gene mutation.
Posted ContentDOI
Generation of functional heart organoids from mouse embryonic stem cells.
TL;DR: Jiyoung Lee ( jlee.epgn@mri.tmd.ac.jp) Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University https://orcid.org/0000-0001-7717-8104.
References
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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
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Protein modules and signalling networks
TL;DR: This work highlights conserved protein domains that act as key regulatory participants in many of these different signalling pathways in multicellular organisms.
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Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
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Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.