Journal ArticleDOI
Gut Microbiota in Health and Disease
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TLDR
The advances in modeling and analysis of gut microbiota will further the authors' knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.Abstract:
Gut microbiota is an assortment of microorganisms inhabiting the length and width of the mammalian gastrointestinal tract. The composition of this microbial community is host specific, evolving throughout an individual's lifetime and susceptible to both exogenous and endogenous modifications. Recent renewed interest in the structure and function of this "organ" has illuminated its central position in health and disease. The microbiota is intimately involved in numerous aspects of normal host physiology, from nutritional status to behavior and stress response. Additionally, they can be a central or a contributing cause of many diseases, affecting both near and far organ systems. The overall balance in the composition of the gut microbial community, as well as the presence or absence of key species capable of effecting specific responses, is important in ensuring homeostasis or lack thereof at the intestinal mucosa and beyond. The mechanisms through which microbiota exerts its beneficial or detrimental influences remain largely undefined, but include elaboration of signaling molecules and recognition of bacterial epitopes by both intestinal epithelial and mucosal immune cells. The advances in modeling and analysis of gut microbiota will further our knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.read more
Citations
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Journal ArticleDOI
Feeding modes shape the acquisition and structure of the initial gut microbiota in newborn lambs.
TL;DR: It was found that suckled and bottle‐fed newborn lambs had their own distinct gut microbiota, which advance the understanding of gut microbiota in early life and may help design techniques to improve gut microbiota and health.
Journal ArticleDOI
Probiotic mixture VSL#3 reduce high fat diet induced vascular inflammation and atherosclerosis in ApoE(-/-) mice.
YK Chan,Hani El-Nezami,Hani El-Nezami,Yan Chen,Kristiina Kinnunen,Pirkka V. Kirjavainen,Pirkka V. Kirjavainen +6 more
TL;DR: VSL#3 significantly reduced proinflammatory adhesion molecules and risk factors of plaque rupture, reduced vascular inflammation and atherosclerosis to a comparable extent to telmisartan; and V SL#3 treated mice had the most distinctly different intestinal microbiota composition from the control groups.
Journal ArticleDOI
Ferritin-like family proteins in the anaerobe Bacteroides fragilis: when an oxygen storm is coming, take your iron to the shelter
Edson R. Rocha,C. Jeffrey Smith +1 more
TL;DR: An overview of the work carried out is presented to demonstrate that both oxygen-detoxifying enzymes and iron-storage proteins are essential for B. fragilis to survive an adverse oxygen-rich environment.
Journal ArticleDOI
In ovo evaluation of FloraMax®-B11 on Marek's disease HVT vaccine protective efficacy, hatchability, microbiota composition, morphometric analysis, and Salmonella enteritidis infection in broiler chickens.
K.D. Teague,L.E. Graham,John R. Dunn,Hans H. Cheng,Nicholas B. Anthony,Juan D. Latorre,A. Menconi,Ross Wolfenden,A. D. Wolfenden,Brittany D. Mahaffey,Mikayla F. A. Baxter,Xochitl Hernandez-Velasco,Ruben Merino-Guzman,Lisa Bielke,Billy M. Hargis,Guillermo Tellez +15 more
TL;DR: The results suggest that in ovo administration of FM does not negatively impact the ability of HVT to protect against MD or hatchability of chickens, but improves BW during the first 7 d of life and decreases SE recovery in chickens.
Journal ArticleDOI
The Intestinal Microbiome in Bariatric Surgery Patients
TL;DR: The physiological and psychological traits exhibited by bariatric surgery candidates that can be influenced by the intestinal microbiota are discussed and the studies that investigated the impact ofbariatric surgery on the intestine microbiota in humans and mouse models of this procedure are detailed.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Journal ArticleDOI
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