Journal ArticleDOI
Gut Microbiota in Health and Disease
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TLDR
The advances in modeling and analysis of gut microbiota will further the authors' knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.Abstract:
Gut microbiota is an assortment of microorganisms inhabiting the length and width of the mammalian gastrointestinal tract. The composition of this microbial community is host specific, evolving throughout an individual's lifetime and susceptible to both exogenous and endogenous modifications. Recent renewed interest in the structure and function of this "organ" has illuminated its central position in health and disease. The microbiota is intimately involved in numerous aspects of normal host physiology, from nutritional status to behavior and stress response. Additionally, they can be a central or a contributing cause of many diseases, affecting both near and far organ systems. The overall balance in the composition of the gut microbial community, as well as the presence or absence of key species capable of effecting specific responses, is important in ensuring homeostasis or lack thereof at the intestinal mucosa and beyond. The mechanisms through which microbiota exerts its beneficial or detrimental influences remain largely undefined, but include elaboration of signaling molecules and recognition of bacterial epitopes by both intestinal epithelial and mucosal immune cells. The advances in modeling and analysis of gut microbiota will further our knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.read more
Citations
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Journal ArticleDOI
Gut microbiota, a new frontier to understand traditional Chinese medicines.
TL;DR: This review summarized the interactions between TCM and gut microbiota, and the pharmacological effects and features of metabolites produced during interactions betweenTCM and Gut microbiota, focusing on gut microbiota and metabolites.
Journal ArticleDOI
Deviations in human gut microbiota: a novel diagnostic test for determining dysbiosis in patients with IBS or IBD
C. Casén,Heidi Vebø,Monika Sekelja,F.T. Hegge,M. K. Karlsson,Ewa Ciemniejewska,S. Dzankovic,C. Frøyland,R. Nestestog,Lars Engstrand,Pia Munkholm,Ole Haagen Nielsen,Gerhard Rogler,Magnus Simren,Lena Öhman,Morten H. Vatn,Morten H. Vatn,Knut Rudi +17 more
TL;DR: Dysbiosis is associated with many diseases, including irritable bowel syndrome, inflammatory bowel diseases, obesity and diabetes and potential clinical impact of imbalance in the intestinal microbiota suggests need for new standardised diagnostic methods to facilitate microbiome profiling.
Journal ArticleDOI
Interactions between Intestinal Microbiota and Host Immune Response in Inflammatory Bowel Disease.
TL;DR: The crosstalk between gut microbiota and host immune response and the contribution of this interaction to the pathogenesis of IBD is highlighted and potential therapeutic strategies targeting the intestinal micro-ecosystem in IBD are discussed.
Journal ArticleDOI
Systematic review: exercise-induced gastrointestinal syndrome - implications for health and intestinal disease
TL;DR: “Exercise‐induced gastrointestinal syndrome” refers to disturbances of gastrointestinal integrity and function that are common features of strenuous exercise.
Journal ArticleDOI
Autism Spectrum Disorders and the Gut Microbiota.
Antonella Fattorusso,Lorenza Di Genova,Giovanni Battista Dell'Isola,Elisabetta Mencaroni,Susanna Esposito +4 more
TL;DR: Analysis of the literature showed that gut dysbiosis in ASD has been widely demonstrated, but there is no single distinctive profile of the composition of the microbiota in people with ASD, and probiotics are still the most promising treatment for neurobehavioural symptoms and bowel dysfunction.
References
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