Journal ArticleDOI
Gut Microbiota in Health and Disease
TLDR
The advances in modeling and analysis of gut microbiota will further the authors' knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.Abstract:
Gut microbiota is an assortment of microorganisms inhabiting the length and width of the mammalian gastrointestinal tract. The composition of this microbial community is host specific, evolving throughout an individual's lifetime and susceptible to both exogenous and endogenous modifications. Recent renewed interest in the structure and function of this "organ" has illuminated its central position in health and disease. The microbiota is intimately involved in numerous aspects of normal host physiology, from nutritional status to behavior and stress response. Additionally, they can be a central or a contributing cause of many diseases, affecting both near and far organ systems. The overall balance in the composition of the gut microbial community, as well as the presence or absence of key species capable of effecting specific responses, is important in ensuring homeostasis or lack thereof at the intestinal mucosa and beyond. The mechanisms through which microbiota exerts its beneficial or detrimental influences remain largely undefined, but include elaboration of signaling molecules and recognition of bacterial epitopes by both intestinal epithelial and mucosal immune cells. The advances in modeling and analysis of gut microbiota will further our knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.read more
Citations
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Journal ArticleDOI
The Characteristics and Function of Bacterial Lipopolysaccharides and Their Endotoxic Potential in Humans
TL;DR: This review focuses on the cross-talk between enteral commensal bacteria and the human immune system via LPS and explains the structural characterisation of the LPS molecule and its function in the bacteria.
Journal ArticleDOI
A review of fermented foods with beneficial effects on brain and cognitive function
Binna Kim,Veronica Minsu Hong,Jeongwon Yang,Heejung Hyun,Jooyeon Jamie Im,Jaeuk Hwang,Sujung Yoon,Ji-Eun Kim +7 more
TL;DR: An extensive review of fermented foods and their potential cognitive benefits is reviewed with particular emphasis on cognitive enhancement and neuroprotective effects to promote commercially feasible applications of fermentation foods as natural remedies to cognitive problems.
Journal ArticleDOI
Gut Microbiota as a Target for Preventive and Therapeutic Intervention against Food Allergy.
Rosita Aitoro,Lorella Paparo,Antonio Amoroso,Margherita Di Costanzo,Linda Cosenza,Viviana Granata,Carmen Di Scala,Rita Nocerino,Giovanna Trinchese,Mariangela Montella,Danilo Ercolini,Roberto Berni Canani +11 more
TL;DR: The gut microbiota plays a pivotal role in immune system development and function and the potential role of gut microbiota as the target of intervention against food allergy is presented.
Journal ArticleDOI
Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.
Jihyun F. Kim,Haeyoung Jeong,Dong Su Yu,Dong Su Yu,Sang Haeng Choi,Cheol Goo Hur,Myeong Soo Park,Sung Ho Yoon,Dae-Won Kim,Geun Eog Ji,Hong Seog Park,Hong Seog Park,Tae Kwang Oh +12 more
TL;DR: Biological functions encoded in a single circular chromosome of 1,933,695 bp are suggestive of their probiotic functions, such as utilization of bifidogenic factors and a variety of glycosidic enzymes and biosynthesis of polysaccharides.
Book ChapterDOI
Lactobacillus: host-microbe relationships.
John O'Callaghan,Paul W. O'Toole +1 more
TL;DR: The microbiological complexity of this extraordinarily diverse genus, where lactobacilli are found in or on humans, what responses their presence elicits, and what microbial interaction and effector molecules have been identified are overviewed.
References
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Journal ArticleDOI
Microbial ecology: Human gut microbes associated with obesity
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