Journal ArticleDOI
Gut Microbiota in Health and Disease
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TLDR
The advances in modeling and analysis of gut microbiota will further the authors' knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.Abstract:
Gut microbiota is an assortment of microorganisms inhabiting the length and width of the mammalian gastrointestinal tract. The composition of this microbial community is host specific, evolving throughout an individual's lifetime and susceptible to both exogenous and endogenous modifications. Recent renewed interest in the structure and function of this "organ" has illuminated its central position in health and disease. The microbiota is intimately involved in numerous aspects of normal host physiology, from nutritional status to behavior and stress response. Additionally, they can be a central or a contributing cause of many diseases, affecting both near and far organ systems. The overall balance in the composition of the gut microbial community, as well as the presence or absence of key species capable of effecting specific responses, is important in ensuring homeostasis or lack thereof at the intestinal mucosa and beyond. The mechanisms through which microbiota exerts its beneficial or detrimental influences remain largely undefined, but include elaboration of signaling molecules and recognition of bacterial epitopes by both intestinal epithelial and mucosal immune cells. The advances in modeling and analysis of gut microbiota will further our knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.read more
Citations
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Journal ArticleDOI
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
John F. Cryan,Timothy G. Dinan +1 more
TL;DR: The emerging concept of a microbiota–gut–brain axis suggests that modulation of the gut microbiota may be a tractable strategy for developing novel therapeutics for complex CNS disorders.
Journal ArticleDOI
The gut microbiota — masters of host development and physiology
TL;DR: The gut microbiota has a beneficial role during normal homeostasis, modulating the host's immune system as well as influencing host development and physiology, including organ development and morphogenesis, and host metabolism.
Journal ArticleDOI
Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis
Jessica M. Yano,Kristie B. Yu,Gregory P. Donaldson,Gauri G. Shastri,Phoebe Ann,Liang Ma,Cathryn R. Nagler,Rustem F. Ismagilov,Sarkis K. Mazmanian,Elaine Y. Hsiao +9 more
TL;DR: It is demonstrated that Indigenous spore-forming bacteria from the mouse and human microbiota promote 5-HT biosynthesis from colonic enterochromaffin cells (ECs), which supply 5- HT to the mucosa, lumen, and circulating platelets and elevating luminal concentrations of particular microbial metabolites increases colonic and blood5-HT in germ-free mice.
Journal ArticleDOI
The Microbiota-Gut-Brain Axis
John F. Cryan,Kenneth J. O’Riordan,Caitlin S. M. Cowan,Kiran V. Sandhu,Thomaz F.S. Bastiaanssen,Marcus Boehme,Martín Gabriel Codagnone,Sofia Cussotto,Christine Fülling,Anna V. Golubeva,Katherine E. Guzzetta,Minal Jaggar,Caitriona M. Long-Smith,Joshua M. Lyte,Jason A. Martin,Alicia Molinero-Perez,Gerard M. Moloney,Emanuela Morelli,Enrique Morillas,Rory C. O'Connor,Joana S Cruz-Pereira,Veronica L. Peterson,Kieran Rea,Nathaniel L. Ritz,Eoin Sherwin,Simon Spichak,Emily M. Teichman,Marcel van de Wouw,Ana Paula Ventura-Silva,Shauna E. Wallace-Fitzsimons,Niall P. Hyland,Gerard Clarke,Timothy G. Dinan +32 more
TL;DR: Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.
References
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Journal ArticleDOI
Decreased Diversity of the Fecal Microbiome in Recurrent Clostridium difficile—Associated Diarrhea
Ju Young Chang,Dionysios A. Antonopoulos,Apoorv Kalra,Adriano R. Tonelli,Walid Khalife,Thomas M. Schmidt,Vincent B. Young +6 more
TL;DR: The fecal communities in patients with recurrent CDAD were highly variable in bacterial composition and were characterized by markedly decreased diversity, suggesting preservation and restoration of the microbial diversity could represent novel strategies for prevention and treatment of recurrentCDAD.
Journal ArticleDOI
Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
Djahida Bouskra,Christophe Brézillon,Marion Bérard,Catherine Werts,Catherine Werts,Rosa Varona,Ivo G. Boneca,Ivo G. Boneca,Gérard Eberl +8 more
TL;DR: It is shown that peptidoglycan from Gram-negative bacteria is necessary and sufficient to induce the genesis of ILFs in mice through recognition by the NOD1 (nucleotide-binding oligomerization domain containing 1) innate receptor in epithelial cells, and β-defensin 3- and CCL20-mediated signalling through the chemokine receptor CCR6.
Journal ArticleDOI
Molecular analysis of the bacterial microbiota in the human stomach
Elisabeth M. Bik,Paul B. Eckburg,Steven R. Gill,Karen E. Nelson,Elizabeth Purdom,Fritz Francois,Guillermo I. Perez-Perez,Martin J. Blaser,David A. Relman +8 more
TL;DR: Bacterial diversity within the human gastric mucosa was characterized by using a small subunit 16S rDNA clone library approach and sequences generated by broad-range bacterial PCR from 23 gastric endoscopic biopsy samples were analyzed, featuring diversity at this site greater than previously described.
Journal ArticleDOI
Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota
Bärbel Stecher,Riccardo Robbiani,Alan W. Walker,Astrid M. Westendorf,Manja Barthel,Marcus Kremer,Samuel Chaffron,Andrew J. Macpherson,Jan Buer,Julian Parkhill,Gordon Dougan,Christian von Mering,Wolf-Dietrich Hardt +12 more
TL;DR: Manipulation of the intestinal microbiota by the enteropathogenic bacterium Salmonella enterica subspecies 1 serovar Typhimurium in a mouse colitis model reveals a new concept in infectious disease: in contrast to current thinking, inflammation is not always detrimental for the pathogen.
Journal ArticleDOI
Principles and clinical implications of the brain-gut-enteric microbiota axis.
TL;DR: Enterochromaffin cells are important bidirectional transducers that regulate communication between the gut lumen and the nervous system, and may have an important role in pain and immune-response modulation, control of background emotions and other homeostatic functions.
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