Journal ArticleDOI
Gut Microbiota in Health and Disease
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TLDR
The advances in modeling and analysis of gut microbiota will further the authors' knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.Abstract:
Gut microbiota is an assortment of microorganisms inhabiting the length and width of the mammalian gastrointestinal tract. The composition of this microbial community is host specific, evolving throughout an individual's lifetime and susceptible to both exogenous and endogenous modifications. Recent renewed interest in the structure and function of this "organ" has illuminated its central position in health and disease. The microbiota is intimately involved in numerous aspects of normal host physiology, from nutritional status to behavior and stress response. Additionally, they can be a central or a contributing cause of many diseases, affecting both near and far organ systems. The overall balance in the composition of the gut microbial community, as well as the presence or absence of key species capable of effecting specific responses, is important in ensuring homeostasis or lack thereof at the intestinal mucosa and beyond. The mechanisms through which microbiota exerts its beneficial or detrimental influences remain largely undefined, but include elaboration of signaling molecules and recognition of bacterial epitopes by both intestinal epithelial and mucosal immune cells. The advances in modeling and analysis of gut microbiota will further our knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.read more
Citations
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Journal ArticleDOI
Allobaculum Involves in the Modulation of Intestinal ANGPTLT4 Expression in Mice Treated by High-Fat Diet.
TL;DR: In this paper, the effects of high-fat diets on the Gut Microbiota were investigated in mice with C57BL/6J CGM and 16S rRNA gene sequencing.
Journal ArticleDOI
Microbiota and mitobiota. Putting an equal sign between mitochondria and bacteria.
Dmitry B. Zorov,Egor Y. Plotnikov,Denis N. Silachev,Ljubava D. Zorova,Irina B. Pevzner,S. D. Zorov,V. A. Babenko,S. S. Jankauskas,Vasily A. Popkov,P. S. Savina +9 more
TL;DR: The recent revival of old theories and setting them on modern scientific rails to a large extent are also relevant to mitochondrial science, and the processes inherent to mitochondrial physiology can be revised based on their comparative analysis with possible involvement of bacteria.
Journal ArticleDOI
Molecular characterization of alterations in the intestinal microbiota of patients with grade 3 hypertension.
TL;DR: The gut microbiome of the hypertensive individuals was found to be more diverse than that of the healthy controls, and the mechanism of these changes in microbial composition may open up new insights, and help to treat hypertension and other related diseases.
Journal ArticleDOI
Diagnostics and therapeutic implications of gut microbiota alterations in cardiometabolic diseases.
TL;DR: The role of gut microbiota in host physiology as well as in the pathophysiology of the most common cardio-metabolic disorders are summarized, discussing the potential therapeutic opportunities offered by interventions aimed at modifying microbiome composition and activity.
Journal ArticleDOI
Sisters in arms: myeloid and tubular epithelial cells shape renal innate immunity.
TL;DR: Evidence is highlighted that renal epithelial cells are endowed with such defensive capabilities and as such fully participate in renal innate immune responses.
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