Journal ArticleDOI
Gut Microbiota in Health and Disease
TLDR
The advances in modeling and analysis of gut microbiota will further the authors' knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.Abstract:
Gut microbiota is an assortment of microorganisms inhabiting the length and width of the mammalian gastrointestinal tract. The composition of this microbial community is host specific, evolving throughout an individual's lifetime and susceptible to both exogenous and endogenous modifications. Recent renewed interest in the structure and function of this "organ" has illuminated its central position in health and disease. The microbiota is intimately involved in numerous aspects of normal host physiology, from nutritional status to behavior and stress response. Additionally, they can be a central or a contributing cause of many diseases, affecting both near and far organ systems. The overall balance in the composition of the gut microbial community, as well as the presence or absence of key species capable of effecting specific responses, is important in ensuring homeostasis or lack thereof at the intestinal mucosa and beyond. The mechanisms through which microbiota exerts its beneficial or detrimental influences remain largely undefined, but include elaboration of signaling molecules and recognition of bacterial epitopes by both intestinal epithelial and mucosal immune cells. The advances in modeling and analysis of gut microbiota will further our knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.read more
Citations
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Journal ArticleDOI
Association Between Gut Microbiota and Helicobacter pylori-Related Gastric Lesions in a High-Risk Population of Gastric Cancer.
Juan-Juan Gao,Yang Zhang,Markus Gerhard,Raquel Mejías-Luque,Lian Zhang,Michael Vieth,Jun-Ling Ma,Monther Bajbouj,Stepan Suchanek,Wei-Dong Liu,Kurt Ulm,Michael Quante,Zhe-Xuan Li,Tong Zhou,Roland M. Schmid,Meinhard Classen,Wen-Qing Li,Wei-Cheng You,Kai-Feng Pan +18 more
TL;DR: The findings suggest that the alterations of fecal microbiota, especially the dominant phyla of Bacteroidetes, Firmicutes and Proteobacteria, may be involved in the process of H. pylori-related gastric lesion progression and provide hints for future evaluation of microbial changes after H.pylori eradication.
Journal ArticleDOI
Lactobacillus rhamnosus GG: An Overview to Explore the Rationale of Its Use in Cancer.
Giuseppe Luigi Banna,Francesco Torino,Francesco Marletta,Maria Santagati,Rossella Salemi,Elisa Cannarozzo,Luca Falzone,Francesco Ferraù,Massimo Libra +8 more
TL;DR: Encouraging data support further investigation on the use of LGG in stratified patients undergoing specific therapeutic protocols, including chemotherapy and pelvic radiotherapy, in order to reduce the development of severe diarrhea and thus improve the adherence to the therapy and patients’ quality of life.
Journal ArticleDOI
Dysbiosis in gastrointestinal disorders
Christopher Chang,Henry Lin +1 more
TL;DR: The contributions of intestinal microbiota in GI diseases should offer novel insight into disease pathophysiology and deliver new treatment strategies such as therapeutic manipulation of the microbiota.
Journal ArticleDOI
The colonic microbiota in health and disease
TL;DR: Advances in understanding host–microbe interactions in the gut continue apace, they are relevant to a diversity of infectious, inflammatory, neoplastic and metabolic disorders and are poised for clinical translation.
Journal ArticleDOI
Molecular Players Involved in the Interaction Between Beneficial Bacteria and the Immune System.
TL;DR: This review intends to summarize the molecular players produced by probiotic bacteria, notably Lactobacillus and Bifidobacterium strains, but also other very promising potential probiotics, which affect the human immune system.
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