Journal ArticleDOI
Gut Microbiota in Health and Disease
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TLDR
The advances in modeling and analysis of gut microbiota will further the authors' knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.Abstract:
Gut microbiota is an assortment of microorganisms inhabiting the length and width of the mammalian gastrointestinal tract. The composition of this microbial community is host specific, evolving throughout an individual's lifetime and susceptible to both exogenous and endogenous modifications. Recent renewed interest in the structure and function of this "organ" has illuminated its central position in health and disease. The microbiota is intimately involved in numerous aspects of normal host physiology, from nutritional status to behavior and stress response. Additionally, they can be a central or a contributing cause of many diseases, affecting both near and far organ systems. The overall balance in the composition of the gut microbial community, as well as the presence or absence of key species capable of effecting specific responses, is important in ensuring homeostasis or lack thereof at the intestinal mucosa and beyond. The mechanisms through which microbiota exerts its beneficial or detrimental influences remain largely undefined, but include elaboration of signaling molecules and recognition of bacterial epitopes by both intestinal epithelial and mucosal immune cells. The advances in modeling and analysis of gut microbiota will further our knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.read more
Citations
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Journal ArticleDOI
Gut Lactobacillus protects against the progression of renal damage by modulating the gut environment in rats
Ayumi Yoshifuji,Shu Wakino,Junichiro Irie,Takaya Tajima,Kazuhiro Hasegawa,Takeshi Kanda,Hirobumi Tokuyama,Koichi Hayashi,Hiroshi Itoh +8 more
TL;DR: Lact supplementation mitigated the systemic inflammation and proteinuria associated with renal failure, suggesting that in the gut microbiota, Lact plays a protective role against the progression of CKD.
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Hypothesis: Bacteria Control Host Appetites
TL;DR: It is proposed that a positive-feedback loop exists between the preferences of the host for a particular dietary regimen, the composition of the gut microbiota that depends on this regimen, and the preferencesof the host as influenced by the Gut microbiota.
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When the Nose Doesn't Know: Canine Olfactory Function Associated With Health, Management, and Potential Links to Microbiota
TL;DR: The objective of this literature review is to discuss the specific effects of health, management, and microbiota shifts on olfactory performance in working canines.
Journal ArticleDOI
Characterization of bacterial isolates from the microbiota of mothers' breast milk and their infants
TL;DR: In this study, gram positive bacteria isolated from mothers' breast milk as well as their infants exhibited diversity in GI transit survival and acid inhibition of pathogens, but demonstrated limited ability to produce bacteriocins.
Journal ArticleDOI
Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal Disorders.
TL;DR: The pathophysiology of FGIDs is based on alterations of the gut microbiota/gut hormone axis, which have crucial effects on GI motility.
References
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