L
Laura M. Raffield
Researcher at University of North Carolina at Chapel Hill
Publications - 179
Citations - 4816
Laura M. Raffield is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 23, co-authored 124 publications receiving 1948 citations. Previous affiliations of Laura M. Raffield include Medical University of South Carolina & Wake Forest University.
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Journal ArticleDOI
Inherited causes of clonal haematopoiesis in 97,691 whole genomes.
Alexander G. Bick,Joshua S. Weinstock,Satish K. Nandakumar,Satish K. Nandakumar,Charles P. Fulco,Charles P. Fulco,Erik L. Bao,Erik L. Bao,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Mindy D. Szeto,Xiaotian Liao,Xiaotian Liao,Matthew Leventhal,Joseph Nasser,Kyle Chang,Cecelia A. Laurie,Bala Bharathi Burugula,Christopher J. Gibson,Amy E. Lin,Margaret A. Taub,François Aguet,Kristin G. Ardlie,Braxton D. Mitchell,Braxton D. Mitchell,Kathleen C. Barnes,Kathleen C. Barnes,Arden Moscati,Myriam Fornage,Susan Redline,Susan Redline,Susan Redline,Bruce M. Psaty,Edwin K. Silverman,Edwin K. Silverman,Scott T. Weiss,Scott T. Weiss,Nicholette D. Palmer,Ramachandran S. Vasan,Esteban G. Burchard,Sharon L.R. Kardia,Jiang He,Robert C. Kaplan,Robert C. Kaplan,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Donna K. Arnett,David A. Schwartz,Adolfo Correa,Mariza de Andrade,Xiuqing Guo,Barbara A. Konkle,Brian Custer,Juan M. Peralta,Hongsheng Gui,Deborah A. Meyers,Stephen T. McGarvey,Ida Yii-Der Chen,M. Benjamin Shoemaker,Patricia A. Peyser,Jai G. Broome,Stephanie M. Gogarten,Fei Fei Wang,Quenna Wong,May E. Montasser,Michelle Daya,Eimear E. Kenny,Kari E. North,Lenore J. Launer,Brian E. Cade,Brian E. Cade,Joshua C. Bis,Michael H. Cho,Michael H. Cho,Jessica Lasky-Su,Jessica Lasky-Su,Donald W. Bowden,L. Adrienne Cupples,Angel C.Y. Mak,Lewis C. Becker,Jennifer A. Smith,Tanika N. Kelly,Stella Aslibekyan,Susan R. Heckbert,Susan R. Heckbert,Hemant K. Tiwari,Ivana V. Yang,John A. Heit,Steven A. Lubitz,Steven A. Lubitz,Jill M. Johnsen,Joanne E. Curran,Sally E. Wenzel,Daniel E. Weeks,Dabeeru C. Rao,Dawood Darbar,Jee-Young Moon,Russell P. Tracy,Erin J Buth,Nicholas Rafaels,Ruth J. F. Loos,Peter Durda,Yongmei Liu,Lifang Hou,Jiwon Lee,Priyadarshini Kachroo,Priyadarshini Kachroo,Barry I. Freedman,Daniel Levy,Lawrence F. Bielak,James E. Hixson,James S. Floyd,Eric A. Whitsel,Patrick T. Ellinor,Patrick T. Ellinor,Marguerite R. Irvin,Tasha E. Fingerlin,Laura M. Raffield,Sebastian M. Armasu,Marsha M. Wheeler,Ester Cerdeira Sabino,John Blangero,L. Keoki Williams,Bruce D. Levy,Bruce D. Levy,Wayne Huey-Herng Sheu,Dan M. Roden,Eric Boerwinkle,Eric Boerwinkle,JoAnn E. Manson,JoAnn E. Manson,Rasika A. Mathias,Pinkal Desai,Kent D. Taylor,Andrew D. Johnson,Paul L. Auer,Charles Kooperberg,Cathy C. Laurie,Thomas W. Blackwell,Albert V. Smith,Hongyu Zhao,Ethan M. Lange,Leslie A. Lange,Stephen S. Rich,Jerome I. Rotter,James G. Wilson,James G. Wilson,Paul Scheet,Jacob O. Kitzman,Eric S. Lander,Eric S. Lander,Eric S. Lander,Jesse M. Engreitz,Jesse M. Engreitz,Benjamin L. Ebert,Alexander P. Reiner,Alexander P. Reiner,Siddhartha Jaiswal,Gonçalo R. Abecasis,Gonçalo R. Abecasis,Vijay G. Sankaran,Vijay G. Sankaran,Sekar Kathiresan,Pradeep Natarajan,Pradeep Natarajan +165 more
TL;DR: Analysis of high-coverage whole-genome sequences from 97,691 participants of diverse ancestries in the National Heart, Lung, and Blood Institute Trans-omics for Precision Medicine programme enables simultaneous identification of germline and somatic mutations that predispose individuals to clonal expansion of haematopoietic stem cells.
Journal ArticleDOI
The polygenic and monogenic basis of blood traits and diseases
Dragana Vuckovic,Erik L. Bao,Parsa Akbari,Caleb A. Lareau,Abdou Mousas,Tao Jiang,Ming-Huei Chen,Laura M. Raffield,Manuel Tardaguila,Jennifer E. Huffman,Scott C. Ritchie,Karyn Megy,Hannes Ponstingl,Christopher J. Penkett,Patrick K. Albers,Emilie M. Wigdor,Saori Sakaue,Arden Moscati,Regina Manansala,Ken Sin Lo,Huijun Qian,Masato Akiyama,Traci M. Bartz,Yoav Ben-Shlomo,Andrew D Beswick,Jette Bork-Jensen,Erwin P. Bottinger,Jennifer A. Brody,Frank J. A. van Rooij,Kumaraswamy Naidu Chitrala,Peter W.F. Wilson,Hélène Choquet,John Danesh,Emanuele Di Angelantonio,Niki Dimou,Jingzhong Ding,Paul Elliott,Tõnu Esko,Michele K. Evans,Stephan B. Felix,James S. Floyd,Linda Broer,Niels Grarup,Michael H. Guo,Qi Guo,Andreas Greinacher,Jeffrey Haessler,Torben Hansen,J. M. M. Howson,Wei Huang,Eric Jorgenson,Tim Kacprowski,Mika Kähönen,Yoichiro Kamatani,Masahiro Kanai,Savita Karthikeyan,Fotios Koskeridis,Leslie A. Lange,Terho Lehtimäki,Allan Linneberg,Yongmei Liu,Leo-Pekka Lyytikäinen,Ani Manichaikul,Koichi Matsuda,Karen L. Mohlke,Nina Mononen,Yoshinori Murakami,Girish N. Nadkarni,Kjell Nikus,Nathan Pankratz,Oluf Pedersen,Michael Preuss,Bruce M. Psaty,Olli T. Raitakari,Stephen S. Rich,Benjamin Rodriguez,Jonathan D. Rosen,Jerome I. Rotter,Petra Schubert,Cassandra N. Spracklen,Praveen Surendran,Hua Tang,Jean-Claude Tardif,Mohsen Ghanbari,Uwe Völker,Henry Völzke,Nicholas A. Watkins,Stefan Weiss,VA Million Veteran Program,Na Cai,Kousik Kundu,Stephen B. Watt,Klaudia Walter,Alan B. Zonderman,Kelly Cho,Yun Li,Ruth J. F. Loos,Julian C. Knight,Michel Georges,Oliver Stegle,Evangelos Evangelou,Yukinori Okada,David J. Roberts,Michael Inouye,Andrew D. Johnson,Paul L. Auer,William J. Astle,Alexander P. Reiner,Adam S. Butterworth,Willem H. Ouwehand,Guillaume Lettre,Vijay G. Sankaran,Vijay G. Sankaran,Nicole Soranzo +113 more
TL;DR: The results show the power of large-scale blood cell trait GWAS to interrogate clinically meaningful variants across a wide allelic spectrum of human variation.
A catalog of genetic loci associated with kidney function from analyses of a million individuals
Matthias Wuttke,Yong Li,Man Li,Karsten B. Sieber,Mary F. Feitosa,Mathias Gorski,Adrienne Tin,Lihua Wang,Audrey Y. Chu,Anselm Hoppmann,Holger Kirsten,Ayush Giri,Jin-Fang Chai,Gardar Sveinbjornsson,Bamidele O. Tayo,Teresa Nutile,Christian Fuchsberger,Jonathan Marten,Massimiliano Cocca,Sahar Ghasemi,Yizhe Xu,Katrin Horn,Damia Noce,Peter J. van der Most,Sanaz Sedaghat,Zhi Yu,Masato Akiyama,Saima Afaq,Tarunveer S. Ahluwalia,Peter Almgren,Najaf Amin,Johan Ärnlöv,Stephan J. L. Bakker,Nisha Bansal,Daniela Baptista,Sven Bergmann,Mary L. Biggs,Ginevra Biino,Michael Boehnke,Eric Boerwinkle,Mathilde Boissel,Erwin P. Bottinger,Thibaud Boutin,Hermann Brenner,Marco Brumat,Ralph Burkhardt,Adam S. Butterworth,Eric Campana,Archie Campbell,Harry Campbell,Mickaël Canouil,Robert J. Carroll,Eulalia Catamo,John C. Chambers,Miao-Ling Chee,Miao-Li Chee,Xu Chen,Ching-Yu Cheng,Yurong Cheng,Kaare Christensen,Renata Cifkova,Marina Ciullo,Maria Pina Concas,James P. Cook,Josef Coresh,Tanguy Corre,Cinzia Sala,Daniele Cusi,John Danesh,E. Warwick Daw,Martin H. de Borst,Alessandro De Grandi,Renée de Mutsert,Aiko P. J. de Vries,Frauke Degenhardt,Graciela E. Delgado,Ayse Demirkan,Emanuele Di Angelantonio,Katalin Dittrich,Jasmin Divers,Rajkumar Dorajoo,Kai-Uwe Eckardt,Georg Ehret,Paul Elliott,Karlhans Endlich,Michele K. Evans,Janine F. Felix,Valencia Hui Xian Foo,Oscar H. Franco,Andre Franke,Barry I. Freedman,Sandra Freitag-Wolf,Yechiel Friedlander,Philippe Froguel,Ron T. Gansevoort,He Gao,Paolo Gasparini,J. Michael Gaziano,Vilmantas Giedraitis,Christian Gieger,Giorgia Girotto,Franco Giulianini,Martin Gögele,Scott D. Gordon,Daniel F. Gudbjartsson,Vilmundur Gudnason,Toomas Haller,Pavel Hamet,Tamara B. Harris,Catharina A. Hartman,Caroline Hayward,Jacklyn N. Hellwege,Chew-Kiat Heng,Andrew A. Hicks,Edith Hofer,Wei Huang,Nina Hutri-Kähönen,Shih-Jen Hwang,M. Arfan Ikram,Olafur S. Indridason,Erik Ingelsson,Marcus Ising,Vincent W. V. Jaddoe,Johanna Jakobsdottir,Jost B. Jonas,Peter K. Joshi,Navya Shilpa Josyula,Bettina Jung,Mika Kähönen,Yoichiro Kamatani,Candace M. Kammerer,Masahiro Kanai,Mika Kastarinen,Shona M. Kerr,Chiea Chuen Khor,Wieland Kiess,Marcus E. Kleber,Wolfgang Koenig,Jaspal S. Kooner,Antje Körner,Peter Kovacs,Aldi T. Kraja,Alena Krajčoviechová,Holly Kramer,Bernhard K. Krämer,Florian Kronenberg,Michiaki Kubo,Brigitte Kühnel,Mikko Kuokkanen,Johanna Kuusisto,Martina La Bianca,Markku Laakso,Leslie A. Lange,Carl D. Langefeld,Jeannette Lee,Benjamin Lehne,Terho Lehtimäki,Wolfgang Lieb,Su Chi Lim,Lars Lind,Cecilia M. Lindgren,Jun Liu,Jianjun Liu,Markus Loeffler,Ruth J. F. Loos,Susanne Lucae,Mary Ann Lukas,Leo-Pekka Lyytikäinen,Reedik Mägi,Patrik K. E. Magnusson,Anubha Mahajan,Nicholas G. Martin,Jade Martins,Winfried März,Deborah Mascalzoni,Koichi Matsuda,Christa Meisinger,Thomas Meitinger,Olle Melander,Andres Metspalu,Evgenia K. Mikaelsdottir,Yuri Milaneschi,Kozeta Miliku,Pashupati P. Mishra,VA Million Veteran Program,Karen L. Mohlke,Nina Mononen,Grant W. Montgomery,Dennis O. Mook-Kanamori,Josyf C. Mychaleckyj,Girish N. Nadkarni,Mike A. Nalls,Matthias Nauck,Kjell Nikus,Boting Ning,Ilja M. Nolte,Raymond Noordam,Jeffrey R. O'Connell,Michelle L. O'Donoghue,Isleifur Olafsson,Albertine J. Oldehinkel,Marju Orho-Melander,Willem H. Ouwehand,Sandosh Padmanabhan,Nicholette D. Palmer,Runolfur Palsson,Brenda W.J.H. Penninx,Thomas T. Perls,Markus Perola,Mario Pirastu,Nicola Pirastu,Giorgio Pistis,Anna I. Podgornaia,Ozren Polasek,Belen Ponte,David J. Porteous,Tanja Poulain,Peter P. Pramstaller,Michael Preuss,Bram P. Prins,Michael A. Province,Ton J. Rabelink,Laura M. Raffield,Olli T. Raitakari,Dermot F. Reilly,Rainer Rettig,Myriam Rheinberger,Kenneth Rice,Paul M. Ridker,Fernando Rivadeneira,Federica Rizzi,David J. Roberts,Antonietta Robino,Peter Rossing,Igor Rudan,Rico Rueedi,Daniela Ruggiero,Kathleen A. Ryan,Yasaman Saba,Charumathi Sabanayagam,Veikko Salomaa,Erika Salvi,Kai-Uwe Saum,Helena Schmidt,Reinhold Schmidt,Ben Schöttker,Christina-Alexandra Schulz,Nicole Schupf,Christian M. Shaffer,Yuan Shi,Albert V. Smith,Blair H. Smith,Nicole Soranzo,Cassandra N. Spracklen,Konstantin Strauch,Heather M. Stringham,Michael Stumvoll,Per Svensson,Silke Szymczak,E-Shyong Tai,Salman M. Tajuddin,Nicholas Y. Q. Tan,Kent D. Taylor,Andrej Teren,Yih Chung Tham,Joachim Thiery,Chris H. L. Thio,Hauke Thomsen,Gudmar Thorleifsson,Daniela Toniolo,Anke Tönjes,Johanne Tremblay,Ioanna Tzoulaki,André G. Uitterlinden,Simona Vaccargiu,Rob M. van Dam,Pim van der Harst,Cornelia M. van Duijn,Digna R. Velez Edward,Niek Verweij,Suzanne Vogelezang,Uwe Völker,Peter Vollenweider,Gérard Waeber,Melanie Waldenberger,Lars Wallentin,Ya Xing Wang,Chaolong Wang,Dawn M. Waterworth,Wen Bin Wei,Harvey D. White,John Whitfield,Sarah H. Wild,James F. Wilson,Mary K. Wojczynski,Charlene A. Wong,Tien Yin Wong,Liang Xu,Qiong Yang,Masayuki Yasuda,Laura M. Yerges-Armstrong,Weihua Zhang,Alan B. Zonderman,Jerome I. Rotter,Murielle Bochud,Bruce M. Psaty,Veronique Vitart,James G. Wilson,Abbas Dehghan,Afshin Parsa,Daniel I. Chasman,Kevin Ho,Andrew P. Morris,Olivier Devuyst,Shreeram Akilesh,Sarah A. Pendergrass,Xueling Sim,Carsten A. Böger,Yukinori Okada,Todd L. Edwards,Harold Snieder,Kari Stefansson,Adriana M. Hung,Iris M. Heid,Markus Scholz,Alexander Teumer,Anna Köttgen,Cristian Pattaro +327 more
TL;DR: Trans-ancestry meta-analysis of estimated glomerular filtration rate (eGFR) from 1,046,070 individuals identifies 264 associated loci, providing a resource of molecular targets for translational research of chronic kidney disease.
Journal ArticleDOI
Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.
Ming-Huei Chen,Laura M. Raffield,Abdou Mousas,Saori Sakaue,Jennifer E. Huffman,Arden Moscati,Bhavi Trivedi,Tao Jiang,Parsa Akbari,Dragana Vuckovic,Erik L. Bao,Xue Zhong,Regina Manansala,Véronique Laplante,Minhui Chen,Ken Sin Lo,Huijun Qian,Caleb A. Lareau,Mélissa Beaudoin,Karen A. Hunt,Masato Akiyama,Traci M. Bartz,Yoav Ben-Shlomo,Andrew D Beswick,Jette Bork-Jensen,Erwin P. Bottinger,Jennifer A. Brody,Frank J. A. van Rooij,Kumaraswamynaidu Chitrala,Kelly Cho,Hélène Choquet,Adolfo Correa,John Danesh,Emanuele Di Angelantonio,Niki Dimou,Jingzhong Ding,Paul Elliott,Tõnu Esko,Michele K. Evans,James S. Floyd,Linda Broer,Niels Grarup,Michael H. Guo,Andreas Greinacher,Jeffrey Haessler,Torben Hansen,Joanna M. M. Howson,Qin Qin Huang,Wei Huang,Eric Jorgenson,Tim Kacprowski,Mika Kähönen,Yoichiro Kamatani,Masahiro Kanai,Savita Karthikeyan,Fotis Koskeridis,Leslie A. Lange,Terho Lehtimäki,Markus M. Lerch,Allan Linneberg,Yongmei Liu,Leo-Pekka Lyytikäinen,Ani Manichaikul,Hilary C. Martin,Koichi Matsuda,Karen L. Mohlke,Nina Mononen,Yoshinori Murakami,Girish N. Nadkarni,Matthias Nauck,Kjell Nikus,Willem H. Ouwehand,Nathan Pankratz,Oluf Pedersen,Michael Preuss,Bruce M. Psaty,Olli T. Raitakari,David J. Roberts,Stephen S. Rich,Benjamin Rodriguez,Jonathan D. Rosen,Jerome I. Rotter,Petra Schubert,Cassandra N. Spracklen,Praveen Surendran,Hua Tang,Jean-Claude Tardif,Richard C. Trembath,Mohsen Ghanbari,Uwe Völker,Henry Völzke,Nicholas A. Watkins,Alan B. Zonderman,VA Million Veteran Program,Peter W.F. Wilson,Yun Li,Adam S. Butterworth,Jean-François Gauchat,Charleston W. K. Chiang,Bingshan Li,Ruth J. F. Loos,William J. Astle,Evangelos Evangelou,David A. van Heel,Vijay G. Sankaran,Yukinori Okada,Nicole Soranzo,Andrew D. Johnson,Alexander P. Reiner,Paul L. Auer,Guillaume Lettre,Guillaume Lettre +111 more
TL;DR: The clinical significance and predictive value of trans-ethnic variants in multiple populations are explored, genetic architecture and the effect of natural selection on these blood phenotypes between populations are compared and the value of a more global representation of populations in genetic studies is highlighted.
Journal ArticleDOI
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels
Adrienne Tin,Jonathan Marten,Victoria L. Halperin Kuhns,Yong Li,Matthias Wuttke,Holger Kirsten,Karsten B. Sieber,Chengxiang Qiu,Mathias Gorski,Mathias Gorski,Zhi Yu,Ayush Giri,Ayush Giri,Gardar Sveinbjornsson,Man Li,Audrey Y. Chu,Anselm Hoppmann,Luke J. O’Connor,Bram P. Prins,Teresa Nutile,Damia Noce,Masato Akiyama,Massimiliano Cocca,Sahar Ghasemi,Peter J. van der Most,Katrin Horn,Yizhe Xu,Christian Fuchsberger,Sanaz Sedaghat,Saima Afaq,Saima Afaq,Najaf Amin,Johan Ärnlöv,Johan Ärnlöv,Stephan J. L. Bakker,Nisha Bansal,Daniela Baptista,Sven Bergmann,Sven Bergmann,Sven Bergmann,Mary L. Biggs,Ginevra Biino,Eric Boerwinkle,Erwin P. Bottinger,Thibaud Boutin,Marco Brumat,Ralph Burkhardt,Ralph Burkhardt,Eric Campana,Archie Campbell,Harry Campbell,Robert J. Carroll,Eulalia Catamo,John C. Chambers,Marina Ciullo,Maria Pina Concas,Josef Coresh,Tanguy Corre,Tanguy Corre,Daniele Cusi,Sala Cinzia Felicita,Martin H. de Borst,Alessandro De Grandi,Renée de Mutsert,Aiko P. J. de Vries,Graciela E. Delgado,Ayse Demirkan,Ayse Demirkan,Olivier Devuyst,Katalin Dittrich,Kai-Uwe Eckardt,Kai-Uwe Eckardt,Georg Ehret,Karlhans Endlich,Michele K. Evans,Ron T. Gansevoort,Paolo Gasparini,Vilmantas Giedraitis,Christian Gieger,Giorgia Girotto,Martin Gögele,Scott D. Gordon,Daniel F. Gudbjartsson,Vilmundur Gudnason,Toomas Haller,Pavel Hamet,Tamara B. Harris,Caroline Hayward,Andrew A. Hicks,Edith Hofer,Hilma Holm,Wei Huang,Nina Hutri-Kähönen,Shih-Jen Hwang,M. Arfan Ikram,Raychel M. Lewis,Erik Ingelsson,Johanna Jakobsdottir,Ingileif Jonsdottir,Helgi Jonsson,Peter K. Joshi,Navya Shilpa Josyula,Bettina Jung,Mika Kähönen,Yoichiro Kamatani,Masahiro Kanai,Shona M. Kerr,Wieland Kiess,Marcus E. Kleber,Wolfgang Koenig,Wolfgang Koenig,Jaspal S. Kooner,Antje Körner,Peter Kovacs,Bernhard K. Krämer,Florian Kronenberg,Michiaki Kubo,Brigitte Kühnel,Martina La Bianca,Leslie A. Lange,Benjamin Lehne,Terho Lehtimäki,Jun Liu,Jun Liu,Markus Loeffler,Ruth J. F. Loos,Leo-Pekka Lyytikäinen,Reedik Mägi,Anubha Mahajan,Anubha Mahajan,Nicholas G. Martin,Winfried März,Winfried März,Winfried März,Deborah Mascalzoni,Koichi Matsuda,Christa Meisinger,Thomas Meitinger,Andres Metspalu,Yuri Milaneschi,Christopher J. O'Donnell,Christopher J. O'Donnell,Otis D. Wilson,J. Michael Gaziano,J. Michael Gaziano,Pashupati P. Mishra,Karen L. Mohlke,Nina Mononen,Grant W. Montgomery,Dennis O. Mook-Kanamori,Martina Müller-Nurasyid,Girish N. Nadkarni,Mike A. Nalls,Matthias Nauck,Kjell Nikus,Boting Ning,Ilja M. Nolte,Raymond Noordam,Jeffrey R. O'Connell,Isleifur Olafsson,Sandosh Padmanabhan,Brenda W.J.H. Penninx,Thomas T. Perls,Annette Peters,Mario Pirastu,Nicola Pirastu,Giorgio Pistis,Ozren Polasek,Belen Ponte,David J. Porteous,Tanja Poulain,Michael Preuss,Ton J. Rabelink,Laura M. Raffield,Olli T. Raitakari,Olli T. Raitakari,Rainer Rettig,Myriam Rheinberger,Kenneth Rice,Federica Rizzi,Antonietta Robino,Igor Rudan,Alena Krajčoviechová,Renata Cifkova,Rico Rueedi,Rico Rueedi,Daniela Ruggiero,Kathleen A. Ryan,Yasaman Saba,Erika Salvi,Helena Schmidt,Reinhold Schmidt,Christian M. Shaffer,Albert V. Smith,Blair H. Smith,Cassandra N. Spracklen,Konstantin Strauch,Michael Stumvoll,Patrick Sulem,Salman M. Tajuddin,Andrej Teren,Joachim Thiery,Chris H. L. Thio,Unnur Thorsteinsdottir,Daniela Toniolo,Anke Tönjes,Johanne Tremblay,André G. Uitterlinden,Simona Vaccargiu,Pim van der Harst,Cornelia M. van Duijn,Cornelia M. van Duijn,Cornelia M. van Duijn,Niek Verweij,Uwe Völker,Peter Vollenweider,Gérard Waeber,Melanie Waldenberger,John Whitfield,Sarah H. Wild,James F. Wilson,Qiong Yang,Weihua Zhang,Weihua Zhang,Alan B. Zonderman,Murielle Bochud,James G. Wilson,Sarah A. Pendergrass,Kevin Ho,Afshin Parsa,Afshin Parsa,Peter P. Pramstaller,Bruce M. Psaty,Bruce M. Psaty,Carsten A. Böger,Harold Snieder,Adam S. Butterworth,Yukinori Okada,Todd L. Edwards,Todd L. Edwards,Kari Stefansson,Katalin Susztak,Markus Scholz,Iris M. Heid,Adriana M. Hung,Adriana M. Hung,Alexander Teumer,Cristian Pattaro,Owen M. Woodward,Veronique Vitart,Anna Köttgen,Anna Köttgen +251 more
TL;DR: A trans-ancestry genome-wide association study of serum urate levels identifies 183 loci that improve the prediction of gout in an independent cohort of 334,880 individuals, and implicates the kidney and liver as key target organs and prioritize potential causal genes.