Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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Journal Article
Effects of fibroblast growth factors 19 and 20 on cell multiplication and locomotion in a human embryonal carcinoma cell line (Tera-2) in vitro.
Wilhelm Engström,Marika Granerus +1 more
TL;DR: FGF-19 and FGF-20 qualitatively exert different effects on cell survival and cell locomotion, which is required at high doses to achieve a comparable effect.
Journal ArticleDOI
Prognostic value of FGFR1 expression and amplification in patients with HNSCC: A systematic review and meta-analysis.
Yao Hu,Lisha Ai,Liu-Qing Zhou +2 more
TL;DR: In this article, a meta-analysis was performed to clarify the correlation between FGFR1 and the survival outcomes of head and neck squamous cell carcinoma (HNSCC) patients.
Book ChapterDOI
Stromal Cells and Tumor Microenvironment
TL;DR: The extent to which stroma differs in these tumors is difficult to assess, but it is worth noting that medullary or lymphoepithelioma-like tumors in which lymphocytic infiltrates are prominent may differ from other gastric tumors.
Dissertation
Novel stem cell and PHBHHx approaches to tendon repair
TL;DR: An investigation into whether a controlled production of PHBHHx based nanoparticles could produce different nanoparticles sizes that can be predicted and result in differing release profiles may allow for the synthesis of size controlled nanoparticles capable of delivering differing drug concentrations and sustained release properties.
References
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Journal ArticleDOI
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
Journal ArticleDOI
Protein modules and signalling networks
TL;DR: This work highlights conserved protein domains that act as key regulatory participants in many of these different signalling pathways in multicellular organisms.
Journal ArticleDOI
Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
Journal ArticleDOI
Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.