Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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Journal ArticleDOI
Role of fibroblast growth factors in pancreatic cancer
TL;DR: FGF/FGFR signaling pathway is a perspective specific marker for cancer progression, and a potential drug target, which can be used for treatment of pancreatic cancer.
DissertationDOI
Investigating the contribution of FGF receptors in breast tumorigenesis using models of mammary cancer
TL;DR: This study aimed at a better understanding of how FGFRs contribute to breast tumorigenesis and identified a cohort of patients showing overexpression of genes that were regulated after TKI258 treatment.
Journal ArticleDOI
Expression and functional role of fibroblast growth factors (FGF) in placenta during different stages of pregnancy in water buffalo (Bubalus bubalis)
H. Lakshmi Devi,Subodh Kumar,Y.Y. Konyak,Jaya Bharati,Aamrapali Bhimte,Y. Pandey,Kuldeep Kumar,Avishek Paul,Anju Kala,Hari Abdul Samad,M. R. Verma,Gurmej Singh,Sadhan Bag,Mihir Sarkar,V.S. Chouhan +14 more
TL;DR: Findings corroborate that FGF acts locally in the trophoblast cells to modulate steroid hormone viz. progesterone synthesis, promote angiogenesis and favors cell survivability indicating that this factor may play an essential role in the regulation of placental formation and function in buffalo.
Dissertation
Characterization of the fibroblast growth factor receptor 2 splicing mechanism in triple-negative breast cancer
TL;DR: A thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy in Medicine Johannesburg, 2016 is presented.
Journal ArticleDOI
Ang II (Angiotensin II)–Induced FGFR1 (Fibroblast Growth Factor Receptor 1) Activation in Tubular Epithelial Cells Promotes Hypertensive Kidney Fibrosis and Injury
Zhengwei Xu,Wu Luo,Lingfeng Chen,Zaishou Zhuang,Da-Gui Yang,Jianchang Qian,Zia Khan,Xinfu Guan,Yi Wang,Xiaokun Li,Guang Liang +10 more
TL;DR: In the mouse model of hypertensive kidney disease, genetic knockdown of FGFR1 or pharmacological inhibition of its activity protected kidneys from dysfunction and fibrosis upon Ang II challenge, revealing a novel mechanism causing renal fibrosis in hypertension.
References
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Journal ArticleDOI
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
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Protein modules and signalling networks
TL;DR: This work highlights conserved protein domains that act as key regulatory participants in many of these different signalling pathways in multicellular organisms.
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Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
Journal ArticleDOI
Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.