Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
More filters
Patent
Kgf polypeptide compositions
TL;DR: In this paper, the authors describe compositions comprising of KGF polypeptides and methods of using the same. But they do not discuss the use of the KGF proteins in compositions in lesser amounts than would be necessary using full-length KGF163.
Application of polymer drugs to medical devices and reparative medicine
María Rosa Aguilar,Luis García-Fernández,María Luisa López-Donaire,Francisco Parra,Luis Rojo Del Olmo,Gerardo Rodríguez,Mar Fernández-Gutiérrez,J. San Román +7 more
Journal ArticleDOI
Biochemical characterization of a N-terminal fragment (p5) cleaved from fibroblast growth factor-binding protein (FGF-BP) in bovine milk in vitro.
TL;DR: Results show that p5 has a high binding affinity with aFGF as well as bLF; the binding of SCS to p5 results in the selective inhibition of its phosphorylation by PKA; and SCS functions as an effective stimulator for the phosphorylated p5 by CK1delta in vitro.
Dissertation
Molecular markers of gliomas : implications for diagnosis and new target therapies
Di Stefano,Anna Luisa +1 more
TL;DR: Dans la deuxieme section nous avons optimise une nouvelle sequence de spectroscopie differentielle-MEGA-PRESS-pour the detection of l'oncometabolite 2-hydroxyglutarate (2 HG) qui s'accumule de maniere specifique dans les gliomes IDH mutes.
Journal ArticleDOI
Construction and Characterization of a Novel Superantigen Fusion Protein: bFGF/SEB
TL;DR: The recombinant bFGF/SEB-fusion protein was shown to retain the superantigenic activity of SEB, and might be a novel promising immunotherapeutic agent for the treatment of some carcinomas.
References
More filters
Journal ArticleDOI
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
Journal ArticleDOI
Protein modules and signalling networks
TL;DR: This work highlights conserved protein domains that act as key regulatory participants in many of these different signalling pathways in multicellular organisms.
Journal ArticleDOI
Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
Journal ArticleDOI
Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.