Institution
Mitsubishi
Company•Tokyo, Japan•
About: Mitsubishi is a company organization based out in Tokyo, Japan. It is known for research contribution in the topics: Signal & Layer (electronics). The organization has 53115 authors who have published 54821 publications receiving 870150 citations. The organization is also known as: Mitsubishi Group of Companies & Mitsubishi Companies.
Topics: Signal, Layer (electronics), Semiconductor memory, Electrode, Voltage
Papers published on a yearly basis
Papers
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TL;DR: Data suggest that Sam68 participates in the signal transduction pathway downstream of TCR-coupled Src family kinases Fyn and Lck in lymphocytes, that is not only in the mitotic pathways downstream of c-Src in fibroblasts.
104 citations
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TL;DR: According to the HER-2/CEP17 ratio and mean HER 2 copies per nucleus, agreement level of HER2/neu amplification was shown to be nearly perfect between two observers as mentioned in this paper.
Abstract: BACKGROUND
Fluorescent in situ hybridization (FISH) has been shown to be one of the most reliable methods with which to estimate the status of the HER-2/neu (or c-erb B-2) oncogene at the DNA level.
METHODS
To study interobserver reproducibility and to determine more clinically correlated criteria for HER-2/neu alterations, two observers independently estimated HER-2/neu DNA status. The correlation between the consensus HER-2/neu DNA status by FISH and HER-2/neu protein status detected by immunohistochemistry (IHC) using a polyclonal antibody was studied in 216 surgically resected breast carcinomas and 34 noncancerous tissues.
RESULTS
According to the HER-2/CEP17 ratio and mean HER-2 copies per nucleus, agreement level of HER-2/neu amplification was shown to be nearly perfect between two observers (kappa statistic (κ) = 0.94 and κ = 0.84). Finally, 40 tumors (19%) were judged to have HER-2/neu DNA amplification, with 6 having low-level amplification (≥ 2 but < 3 folds) and 34 having high-level amplification (≥ 3 folds). One hundred seventy-six other tumors, including 3 tumors that only 1 of the observers determined to be low-level amplifiers, and 34 noncancerous tissues had no detected amplification. The DNA amplification status was concordant between invasive and intraductal components in 14 carcinomas. HER-2/neu protein overexpression of moderate (2+) or high (3+) intensity based on IHC was detected in 51 carcinomas (24%), and was 2+ in 20 carcinomas and 3+ in 31 carcinomas. The HER-2/CEP17 ratio of ≥ 2 was concordant with IHC findings of 2+/3+ in 91% of carcinomas (195 of 215 carcinomas), with a sensitivity of 70% (35 of 50 carcinomas) and a specificity of 97% (160 of 165 carcinomas). High-level amplification was detected in 29 of 31 IHC 3+ cases (94%), but in only 5 of 20 IHC 2+ cases (25%) and 0 in 165 IHC 0/1+ cases. All 34 cases with high-level amplification showed an IHC score of 3+ (29 cases) or an IHC score of 2+ (5 cases), but only 1 case was found to have an IHC score of 3+ and the remainder were IHC 0/1+ in 6 low-amplification cases. The concordance rate of the high-level amplification with an IHC score of 3+ was 97% (208 of 215 cases), with a sensitivity of 94% (29 of 31 cases) and a specificity of 97% (179 of 184 cases).
CONCLUSIONS
The results of the current study indicated that high-level HER-2/neu amplification and an IHC score of 3+ nearly optimally identified breast carcinomas with clinically and biologically significant HER-2/neu activation. Conversely, it was confirmed that careful interpretation of test results is required in the case of low-level amplification and/or an IHC score of 2+. Cancer 2001;92:2965–74. © 2001 American Cancer Society.
104 citations
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TL;DR: In this article, the electrochemical properties of surface films of deposited lithium on nickel substrates in electrolytes with LiN (SO 2 CF 3 ) 2 ) (LiTFSI), LiN(SO 2 C 2 F 5 ) 2 (LiBETI), LiPF 6 solutes, and tetrahydrofuran solvents were characterized by Fourier transform infrared, two-dimensional nuclear magnetic resonance (2D NMR), X-ray photoelectron spectroscopy, evolved gas analysis, and ion chromatograph in order to understand the electro
Abstract: Chemical components of surface films of deposited lithium on nickel substrates in electrolytes with LiN (SO 2 CF 3 ) 2 ) (LiTFSI), LiN (SO 2 C 2 F 5 ) 2 (LiBETI), LiPF 6 solutes, and tetrahydrofuran solvents were characterized by Fourier-transform infrared, two-dimensional nuclear magnetic resonance (2D NMR), X-ray photoelectron spectroscopy, evolved gas analysis, and ion chromatograph in order to understand the electrochemical performance of lithium imide/cyclic ether-based electrolytes The top layers of the surface film were ROCO 2 Li, Li 2 CO 3 , polymer constituents, and LiF The inner layers of the surface film consisted of Li 2 O and carbide species In imide/cyclic ether-based electrolytes, Li 2 S 2 O 4 and Li 2 SO 3 as outer layers, and Li 2 S as the inner layer were formed on a nickel substrate as reductive constituents of imide solute We found that organic surface layers consisted of lithium etoxides, lithium ethylene dicarbonate (CH 2 OCO 2 Li) 2 , polyethylene oxide, and lithium ethylene dicarbonate containing an oxyethylene unit by 1 H, 13 C, and 2D NMR Li cycling efficiency affects not only the deposited lithium morphology but also chemical components
104 citations
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TL;DR: It is concluded that Smt3 was conjugated to Cdc3 in septin rings localized at the mother-bud neck around the time of cytokinesis, and the biological significance of this Smt 3 conjugation to a septin component is discussed.
104 citations
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TL;DR: Using a whole‐cell patch‐clamp technique with rat cerebellar slices, it is found that immunoglobulins present in the cerebrospinal fluid of an ataxic patient acted presynaptically to cause a selective suppression of GABAergic transmission.
Abstract: Humoral immune response to glutamic acid decarboxylase (GAD) has been implicated in the pathogenesis of stiff-man syndrome and cerebellar ataxia, but the underlying pathomechanism is unclear. Using a whole-cell patch-clamp technique with rat cerebellar slices, we found that immunoglobulins present in the cerebrospinal fluid of an ataxic patient acted presynaptically to cause a selective suppression of GABAergic transmission. This synaptic depression was most likely elicited by an autoantibody to GAD.
104 citations
Authors
Showing all 53117 results
Name | H-index | Papers | Citations |
---|---|---|---|
Thomas S. Huang | 146 | 1299 | 101564 |
Kazunari Domen | 130 | 908 | 77964 |
Kozo Kaibuchi | 129 | 493 | 60461 |
Yoshimi Takai | 122 | 680 | 61478 |
William T. Freeman | 113 | 432 | 69007 |
Tadayuki Takahashi | 112 | 932 | 57501 |
Takashi Saito | 112 | 1041 | 52937 |
H. Vincent Poor | 109 | 2116 | 67723 |
Qi Tian | 96 | 1030 | 41010 |
Andreas F. Molisch | 96 | 777 | 47530 |
Takeshi Sakurai | 95 | 492 | 43221 |
Akira Kikuchi | 93 | 412 | 28893 |
Markus Gross | 91 | 588 | 32881 |
Eiichi Nakamura | 90 | 845 | 31632 |
Michael Wooldridge | 87 | 543 | 50675 |