Institution
University of Hawaii at Manoa
Education•Honolulu, Hawaii, United States•
About: University of Hawaii at Manoa is a education organization based out in Honolulu, Hawaii, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 13693 authors who have published 25161 publications receiving 1023924 citations.
Papers published on a yearly basis
Papers
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TL;DR: E+e-→π+π-hc at center-of-mass energies from 3.90 to 4.42 GeV is studied by using data samples collected with the BESIII detector operating at the Beijing Electron Positron Collider and a distinct structure, referred to as Zc(4020), is observed in the π±hc mass spectrum.
Abstract: We study e(+)e(-) -> pi(+) pi(-)h(c) at center-of-mass energies from 3.90 to 4.42 GeV by using data samples collected with the BESIII detector operating at the Beijing Electron Positron Collider. The Born cross sections are measured at 13 energies and are found to be of the same order of magnitude as those of e(+)e(-) -> pi(+) pi(-) J/Psi but with a different line shape. In the pi(+/-)h(c) mass spectrum, a distinct structure, referred to as Z(c)(4020) is observed at 4. 02 GeV/c(2). The Z(c)(4020) carries an electric charge and couples to charmonium. A fit to the pi(+/-)h(c) invariant mass spectrum, neglecting possible interferences, results in a mass of (4022.9 +/- 0.8 +/- 2.7) MeV/c(2) and a width of (7.9 +/- 2.7 +/- 2.6) MeV for the Z(c)(4020), where the first errors are statistical and the second systematic. The difference between the parameters of this structure and the Z(c) (4025) observed in the D*(D) over bar* final state is within 1.5 sigma, but whether they are the same state needs further investigation. No significant Z(c)(3900) signal is observed, and upper limits on the Z(c)(3900) production cross sections in pi +/- h(c) at center-of-mass energies of 4.23 and 4.26 GeVare set.
377 citations
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TL;DR: Brain structural, chemical and metabolic brain changes, particularly those in the basal ganglia, in individuals who used methamphetamine and in children with prenatal methamphetamine exposure are reviewed, demonstrating abnormalities in brain structure and chemistry convincingly.
Abstract: Aims To review structural, chemical and metabolic brain changes, particularly those in the basal ganglia, in individuals who used methamphetamine, as well as in children with prenatal methamphetamine exposure.
Methods Magnetic resonance imaging (MRI) and positron emission tomography (PET) studies that evaluated brain structural, chemical and metabolite changes in methamphetamine subjects, or children with prenatal methamphetamine exposure, were reviewed and summarized. Relevant pre-clinical studies that provided insights to the interpretations of these imaging studies were also reviewed.
Results In adults who used methamphetamine, MRI demonstrates enlarged striatal volumes, while MR spectroscopy shows reduced concentrations of the neuronal marker N-acetylasparate and total creatine in the basal ganglia. In contrast, children with prenatal methamphetamine exposure show smaller striatal structures and elevated total creatine. Furthermore, PET studies consistently showed reduced dopamine transporter (DAT) density and reduced dopamine D2 receptors in the striatum of methamphetamine subjects. PET studies also found lower levels of serotonergic transporter density and vesicular monoamine transporter (VMAT2) across striatal subregions, as well as altered brain glucose metabolism that correlated with severity of psychiatric symptoms in the limbic and orbitofrontal regions.
Conclusion Neuroimaging studies demonstrate abnormalities in brain structure and chemistry convincingly in individuals who used methamphetamine and in children with prenatal methamphetamine exposure, especially in the striatum. However, many important questions remain and larger sample sizes are needed to validate these preliminary observations. Furthermore, longitudinal studies are needed to evaluate the effects of treatment and abstinence on these brain changes and to determine whether imaging, and possibly genetic, markers can be used to predict treatment outcome or relapse.
377 citations
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Deakin University1, Australian Institute of Marine Science2, University of Western Australia3, King Abdullah University of Science and Technology4, University of Maryland Center for Environmental Science5, South Australian Research and Development Institute6, Bedford Institute of Oceanography7, Australian Research Council8, University of California, Santa Cruz9, Spanish National Research Council10, Oregon State University11, Australian Antarctic Division12, Murdoch University13, Macquarie University14, National Oceanic and Atmospheric Administration15, Florida International University16, James Cook University17, University of Hawaii at Manoa18, Alaska SeaLife Center19, University of California, San Diego20, California State University, Long Beach21, Aarhus University22, Natural Environment Research Council23, Centre for Environment, Fisheries and Aquaculture Science24, University of La Rochelle25, University of Tokyo26, San Jose State University27, University of Southampton28, National Oceanography Centre, Southampton29, Marine Biological Association of the United Kingdom30, National Institute of Polar Research31, University of Konstanz32, Max Planck Society33, National Park Service34
TL;DR: This exercise assembled 40 experts to identify key questions in this field, focussing on marine megafauna, which include a broad range of birds, mammals, reptiles, and fish, and shows that the questions have broad applicability to other taxa, including terrestrial animals, flying insects, and swimming invertebrates.
Abstract: It is a golden age for animal movement studies and so an opportune time to assess priorities for future work. We assembled 40 experts to identify key questions in this field, focussing on marine megafauna, which include a broad range of birds, mammals, reptiles, and fish. Research on these taxa has both underpinned many of the recent technical developments and led to fundamental discoveries in the field. We show that the questions have broad applicability to other taxa, including terrestrial animals, flying insects, and swimming invertebrates, and, as such, this exercise provides a useful roadmap for targeted deployments and data syntheses that should advance the field of movement ecology.
375 citations
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TL;DR: The basic concepts of rays, ray tracing algorithms, and radio propagation modeling using ray tracing methods are reviewed to envision propagation modeling in the near future as an intelligent, accurate, and real-time system in which ray tracing plays an important role.
Abstract: This paper reviews the basic concepts of rays, ray tracing algorithms, and radio propagation modeling using ray tracing methods We focus on the fundamental concepts and the development of practical ray tracing algorithms The most recent progress and a future perspective of ray tracing are also discussed We envision propagation modeling in the near future as an intelligent, accurate, and real-time system in which ray tracing plays an important role This review is especially useful for experts who are developing new ray tracing algorithms to enhance modeling accuracy and improve computational speed
375 citations
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TL;DR: Results from multiple species support the antioxidant/anti-inflammatory properties of the prototype compound, astaxanthin, establishing it as an appropriate candidate for development as a therapeutic agent for cardiovascular oxidative stress and inflammation.
Abstract: Oxidative stress and inflammation are implicated in several different manifestations of cardiovascular disease (CVD). They are generated, in part, from the overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) that activate transcriptional messengers, such as nuclear factor-kappaB, tangibly contributing to endothelial dysfunction, the initiation and progression of atherosclerosis, irreversible damage after ischemic reperfusion, and even arrhythmia, such as atrial fibrillation. Despite this connection between oxidative stress and CVD, there are currently no recognized therapeutic interventions to address this important unmet need. Antioxidants that provide a broad, "upstream" approach via ROS/RNS quenching or free radical chain breaking seem an appropriate therapeutic option based on epidemiologic, dietary, and in vivo animal model data. However, human clinical trials with several different well-known agents, such as vitamin E and beta-carotene, have been disappointing. Does this mean antioxidants as a class are ineffective, or rather that the "right" compound(s) have yet to be found, their mechanisms of action understood, and their appropriate targeting and dosages determined? A large class of potent naturally-occurring antioxidants exploited by nature-the oxygenated carotenoids (xanthophylls)-have demonstrated utility in their natural form but have eluded development as successful targeted therapeutic agents up to the present time. This article characterizes the mechanism by which this novel group of antioxidants function and reviews their preclinical development. Results from multiple species support the antioxidant/anti-inflammatory properties of the prototype compound, astaxanthin, establishing it as an appropriate candidate for development as a therapeutic agent for cardiovascular oxidative stress and inflammation.
375 citations
Authors
Showing all 13867 results
Name | H-index | Papers | Citations |
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Pulickel M. Ajayan | 176 | 1223 | 136241 |
Steven N. Blair | 165 | 879 | 132929 |
Qiang Zhang | 161 | 1137 | 100950 |
Jack M. Guralnik | 148 | 453 | 83701 |
Thomas J. Smith | 140 | 1775 | 113919 |
James A. Richardson | 136 | 363 | 75778 |
Donna Neuberg | 135 | 810 | 72653 |
Jian Zhou | 128 | 3007 | 91402 |
Eric F. Bell | 128 | 631 | 72542 |
Jorge Luis Rodriguez | 128 | 834 | 73567 |
Bin Wang | 126 | 2226 | 74364 |
Nicholas J. Schork | 125 | 587 | 62131 |
Matthew Jones | 125 | 1161 | 96909 |
Anthony F. Jorm | 124 | 798 | 67120 |
Adam G. Riess | 118 | 363 | 117310 |